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Title: | Role reversals: non-canonical roles for immune and non-immune cells in the gut. | Austin Authors: | Tearle, Jacqueline L E;Tang, Adelynn;Vasanthakumar, Ajithkumar;James, Kylie R | Affiliation: | Garvan Institute of Medical Research, Darlinghurst, Australia; School of Biomedical Sciences, University of New South Wales, Australia. Olivia Newton-John Cancer Research Institute School of Cancer Medicine, La Trobe University, Bundoora, Australia; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia. Garvan Institute of Medical Research, Darlinghurst, Australia; School of Biomedical Sciences, University of New South Wales, Australia. |
Issue Date: | 13-Nov-2023 | Date: | 2023 | Publication information: | Mucosal Immunology 2023-11-13 | Abstract: | The intestine is home to an intertwined network of epithelial, immune, and neuronal cells as well as the microbiome, with implications for immunity, systemic metabolism, and behaviour. While the complexity of this microenvironment has long since been acknowledged, recent technological advances have propelled our understanding to an unprecedented level. Notably, the microbiota and non-immune or structural cells have emerged as important conductors of intestinal immunity, and by contrast, cells of both the innate and adaptive immune systems have demonstrated non-canonical roles in tissue repair and metabolism. This review highlights recent works in the following two streams: non-immune cells of the intestine performing immunological functions; and traditional immune cells exhibiting non-immune functions in the gut. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/34288 | DOI: | 10.1016/j.mucimm.2023.11.004 | ORCID: | Journal: | Mucosal Immunology | PubMed URL: | 37967720 | ISSN: | 1935-3456 | Type: | Journal Article | Subjects: | epithelial gut-brain axis intestine metabolism stromal |
Appears in Collections: | Journal articles |
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