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Title: Tumor immune evasion: insights from CRISPR screens and future directions.
Austin Authors: Djajawi, Tirta Mario;Wichmann, Johannes;Vervoort, Stephin J;Kearney, Conor J
Affiliation: Olivia Newton-John Cancer Research Institute
The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic., Australia.
School of Cancer Medicine, La Trobe University, Melbourne, Vic., Australia.
Issue Date: 16-Nov-2023
Date: 2023
Publication information: The FEBS Journal 2023-11-16
Abstract: Despite the clinical success of cancer immunotherapies including immune checkpoint blockade and adoptive cellular therapies across a variety of cancer types, many patients do not respond or ultimately relapse; however, the molecular underpinnings of this are not fully understood. Thus, a system-level understating of the routes to tumor immune evasion is required to inform the design of the next generation of immunotherapy approaches. CRISPR screening approaches have proved extremely powerful in identifying genes that promote tumor immune evasion or sensitize tumor cells to destruction by the immune system. These large-scale efforts have brought to light decades worth of fundamental immunology and have uncovered the key immune-evasion pathways subverted in cancers in an acquired manner in patients receiving immune-modulatory therapies. The comprehensive discovery of the main pathways involved in immune evasion has spurred the development and application of novel immune therapies to target this process. Although successful, conventional CRISPR screening approaches are hampered by a number of limitations, which obfuscate a complete understanding of the precise molecular regulation of immune evasion in cancer. Here, we provide a perspective on screening approaches to interrogate tumor-lymphocyte interactions and their limitations, and discuss further development of technologies to improve such approaches and discovery capability.
DOI: 10.1111/febs.17003
ORCID: 0000-0002-9891-5078
Journal: The FEBS Journal
PubMed URL: 37971319
ISSN: 1742-4658
Type: Journal Article
Subjects: CRISPR
immune evasion
Appears in Collections:Journal articles

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