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Title: Systematic review of computed tomography parameters used for the assessment of subchondral bone in osteoarthritis.
Austin Authors: Schadow, Jemima E;Maxey, David;Smith, Toby O;Finnilä, Mikko A J;Manske, Sarah L;Segal, Neil A;Wong, Andy Kin On;Davey, Rachel A;Turmezei, Tom;Stok, Kathryn S
Affiliation: Department of Biomedical Engineering, The University of Melbourne, Melbourne, Australia.
Department of Radiology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom.
Warwick Medical School, University of Warwick, United Kingdom.
Research Unit of Health Science and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Department of Rehabilitation Medicine, The University of Kansas Medical Center, Kansas City, United States.
Joint Department of Medical Imaging, University Health Network, Toronto, Canada; Schroeder's Arthritis Institute, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Medicine (University of Melbourne)
Department of Radiology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom; Norwich Medical School, University of East Anglia, Norwich, United Kingdom.
Department of Biomedical Engineering, The University of Melbourne, Melbourne, Australia.
Issue Date: 3-Nov-2023
Date: 2023
Publication information: Bone 2023-11-03; 178
Abstract: To systematically review the published parameters for the assessment of subchondral bone in human osteoarthritis (OA) using computed tomography (CT) and gain an overview of current practices and standards. A literature search of Medline, Embase and Cochrane Library databases was performed with search strategies tailored to each database (search from 2010 to January 2023). The search results were screened independently by two reviewers against pre-determined inclusion and exclusion criteria. Studies were deemed eligible if conducted in vivo/ex vivo in human adults (>18 years) using any type of CT to assess subchondral bone in OA. Extracted data from eligible studies were compiled in a qualitative summary and formal narrative synthesis. This analysis included 202 studies. Four groups of CT modalities were identified to have been used for subchondral bone assessment in OA across nine anatomical locations. Subchondral bone parameters measuring similar features of OA were combined in six categories: (i) microstructure, (ii) bone adaptation, (iii) gross morphology (iv) mineralisation, (v) joint space, and (vi) mechanical properties. Clinically meaningful parameter categories were identified as well as categories with the potential to become relevant in the clinical field. Furthermore, we stress the importance of quantification of parameters to improve their sensitivity and reliability for the evaluation of OA disease progression and the need for standardised measurement methods to improve their clinical value.
DOI: 10.1016/j.bone.2023.116948
Journal: Bone
Start page: 116948
PubMed URL: 37926204
ISSN: 1873-2763
Type: Journal Article
Subjects: Computed tomography
Subchondral bone
Systematic review
Appears in Collections:Journal articles

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