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Title: Adjunctive Docosahexaenoic Acid in Residual Symptoms of Depression and Anxiety.
Austin Authors: Piperoglou, Michael;Hopwood, Malcolm;Norman, Trevor R 
Affiliation: From the Epworth Hospital, Camberwell.
Department of Psychiatry, University of Melbourne, Melbourne.
Psychiatry (University of Melbourne)
Issue Date: Nov-2023
Date: 2023
Publication information: Journal of Clinical Psychopharmacology 2023-11; 43(6)
Abstract: The aim of the study is to examine the efficacy of omega-3 fatty acid as an adjunct to ongoing pharmacological treatments in patients with residual symptoms of depression and anxiety. This randomized, double-blind, placebo-controlled, cross-over trial was conducted at a single private practice site. Participants were drawn from patients attending the practice.Patients meeting criteria had a 4-week run-in period where they continued to receive their prescribed medications and omega-3 supplements. Depression and anxiety ratings were assessed at recruitment and completion of the run-in phase. Patients were randomized to receive an omega-3 supplement (Neurospark) or placebo once daily for 8 weeks then crossed over to the alternative treatment. At the end of the double-blind, cross-over phase patients received the supplement and were assessed after a 4-week run-out phase.Depression and anxiety symptoms were assessed using the Hamilton scales. Efficacy of treatment was assessed using a linear mixed model analysis with time, order of treatment, diagnosis, and their interaction as factors. Depression and anxiety scales were analyzed as independent measures. The study enrolled 47 patients (mean [SD] age, 46.1 [11.2] years; [59.6%] male). Depression scores did not significantly change across assessments ( P > 0.1); there was no effect of order of treatment ( P > 0.1) or an interaction between time, order of treatment, and psychiatric diagnosis ( P > 0.1). Anxiety scores were similarly unchanged across treatment visits and order of treatment, and there was no interaction between time, order of treatment, and psychiatric diagnosis. Omega-3 fatty acid supplementation did not significantly alter residual symptoms in this group of patients.
DOI: 10.1097/JCP.0000000000001767
ORCID: 0000000334011763
Journal: Journal of Clinical Psychopharmacology
PubMed URL: 37878482
ISSN: 1533-712X
Type: Journal Article
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