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Title: Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control.
Austin Authors: Vajda, Frank;O'Brien, Terence;Graham, Janet;Hitchcock, Alison;Perucca, Piero ;Lander, Cecilie;Eadie, Mervyn
Affiliation: Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia; Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia.
Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia; Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia.
Medicine (University of Melbourne)
Comprehensive Epilepsy Program
Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia.
Issue Date: 13-Oct-2023
Date: 2023
Publication information: Epilepsy & Behavior : E&B 2023-10-13; 148
Abstract: To trace (i) changes in Australian Pregnancy Register (APR) records concerning antiseizure medications (ASMs) prescribed for women with epilepsy (WWE) over the course of 24 years and correlate the changes with (ii) rates of occurrence of pregnancies involving foetal malformations, (iii) the body organs involved in the malformations, and (iv) freedom from epileptic seizures. Use of valproate and carbamazepine decreased progressively, use of lamotrigine remained relatively static, and the use of levetiracetam increased progressively, whereas the use of topiramate first increased and then fell again, associated with a temporary increase in malformation-associated pregnancy rate. More serious malformations, such as spina bifida, became less frequent, whereas more trivial ones tended to increase, whereas epileptic seizure freedom rates improved. The increasing use of newer ASMs in pregnant women has been associated with overall advantages in relation to the frequency and severity of foetal malformation and with advantages in relation to freedom from epileptic seizures.
DOI: 10.1016/j.yebeh.2023.109482
Journal: Epilepsy & Behavior : E&B
Start page: 109482
PubMed URL: 37839246
ISSN: 1525-5069
Type: Journal Article
Subjects: Antiseizure medication (ASM)
Foetal malformation
Seizure control
Appears in Collections:Journal articles

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