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Title: | Diffuse large B-cell lymphoma. | Austin Authors: | Barraclough, Allison ;Hawkes, Eliza A ;Sehn, Laurie H;Smith, Sonali M | Affiliation: | Department of Haematology, Fiona Stanley Hospital, Perth, Western Australia, Australia. Olivia Newton-John Cancer Wellness and Research Centre BC Cancer Centre for Lymphoid Cancer, The University of British Columbia, Vancouver, British Columbia, Canada. The University of Chicago Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois, USA. University of Melbourne, Medical School, Melbourne, Victoria, Australia. Monash University School of Public Health & Preventive Medicine, Melbourne, Victoria, Australia. |
Issue Date: | 12-Jul-2023 | Date: | 2023 | Publication information: | Hematological Oncology 2023-07-12 | Abstract: | Large B-cell lymphoma, the prototype of aggressive non-Hodgkin lymphomas, is both the most common lymphoma and accounts for the highest global burden of lymphoma-related deaths. For nearly 4 decades, the goal of treatment has been "cure", first based on CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and subsequently with rituximab plus CHOP. However, there is significant clinical, pathologic, and biologic heterogeneity, and not all patients are cured. Understanding and incorporating this biologic heterogeneity into treatment decisions unfortunately is not yet standard of care. Despite this gap, we now have significant advances in frontline, relapsed, and refractory settings. The POLARIX trial shows, for the first time, improved progression-free survival in a prospective randomized phase 3 setting. In the relapsed and refractory settings, there are now many approved agents/regimens, and several bispecific antibodies poised to join the arsenal of options. While chimeric antigen receptor T-cell therapy is discussed in detail elsewhere, it has quickly become an excellent option in the second-line setting and beyond. Unfortunately, special populations such as older adults continue to have poor outcomes and be underrepresented in trials, although a new generation of trials aim to address this disparity. This brief review will highlight the key issues and advances that offer improved outcomes to an increasing portion of patients. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/33341 | DOI: | 10.1002/hon.3202 | ORCID: | 0000-0002-9893-4949 | Journal: | Hematological Oncology | PubMed URL: | 37435781 | ISSN: | 1099-1069 | Type: | Journal Article | Subjects: | antibody-drug conjugates diffuse large B-cell lymphoma older adults treatment |
Appears in Collections: | Journal articles |
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