Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33282
Title: Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol.
Austin Authors: Harvey, Lisa A;Glinsky, Joanne V;Chu, Jackie;Herbert, Robert D;Liu, Hueiming;Jan, Stephen;Billot, Laurent;Scivoletto, Giorgio;Spooren, Annemie I;Seelen, Henk A;Ben, Marsha;Tranter, Keira;Chen, Lydia W;Rainey, Donna;Rimmer, Christine;Jorgensen, Vivien;Di Natal, Fernanda;Denis, Sophie;Gollan, Emilie J;Tamburella, Federica;Agostinello, Jacqui;van Laake-Geelen, Charlotte M;Bell, Chris;Lincoln, Claire;Stolwijk, Janneke M;van der Lede, Jessica;Paddison, Sue;Oostra, Kristine;Cameron, Ian D;Weber, Gerard;Sherrington, Catherine;Nunn, Andrew K ;Synnott, Emma-Leigh;McCaughey, Euan;Kaur, Jasbeer;Shetty, Sachin
Affiliation: John Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
John Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
Neuroscience Research Australia (NeuRA), Sydney, NSW, Australia.
The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
I.R.C.C.S. Santa Lucia Foundation, Rome, Italy.
REVAL, Hasselt University, Hasselt, Belgium.
Adelante Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, The Netherlands.
John Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
Royal North Shore Hospital, Sydney, NSW, Australia.
Royal Rehab, Sydney, NSW, Australia.
Fiona Stanley Hospital, Perth, WA, Australia.
Sunnaas Rehabilitation Hospital, Nesodden, Norway.
Prince of Wales Hospital, Sydney, NSW, Australia.
Prince of Wales Hospital, Sydney, NSW, Australia.
The Princess Alexandra Hospital, Brisbane, QLD, Australia.
I.R.C.C.S. Santa Lucia Foundation, Rome, Italy.
The Royal Talbot Rehabilitation Centre, Melbourne, VIC, Australia.
Adelante Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, The Netherlands.;Department of Rehabilitation Medicine, Research School CAPHRI, Maastricht University, Maastricht, The Netherlands.
Repatriation General Hospital, Adelaide, SA, Australia.
Queen Elizabeth National Spinal Injures Unit, Glasgow, UK.
Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.;De Hoogstraat Rehabilitation, Utrecht, The Netherlands.
Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.;De Hoogstraat Rehabilitation, Utrecht, The Netherlands.
London Spinal Cord Injury Centre, Royal National Orthopaedic Hospital Trust, Middlesex, UK.
Ghent University Hospital, Ghent, Belgium.
John Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
Royal Rehab, Sydney, NSW, Australia.
Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Victorian Spinal Cord Service
Fiona Stanley Hospital, Perth, WA, Australia.
Queen Elizabeth National Spinal Injures Unit, Glasgow, UK.
Royal North Shore Hospital, Sydney, NSW, Australia.
Prince of Wales Hospital, Sydney, NSW, Australia.
Issue Date: Sep-2023
Date: 2023
Publication information: Spinal Cord 2023-09; 61(9)
Abstract: Protocol for a multi-centre randomised controlled trial (the SCI-MT trial). To determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI). Fifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium. A pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants' perceptions about ability to perform self-selected goals, length of hospital stay and participants' impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025. The findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI. ACTRN12621000091808 (1.2.2021).
URI: https://ahro.austin.org.au/austinjspui/handle/1/33282
DOI: 10.1038/s41393-023-00908-z
ORCID: 0000-0002-4365-0236
0000-0001-5810-2788
0000-0001-9077-8673
0000-0002-4975-9793
0000-0001-5766-6952
0000-0001-9437-7009
0000-0001-9920-1010
0000-0001-6793-691X
0000-0001-6596-110X
Journal: Spinal Cord
PubMed URL: 37414835
ISSN: 1476-5624
Type: Journal Article
Appears in Collections:Journal articles

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