Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia.

2023-12

Leung, P Y M

Katerelos, M

Choy, S

Cook, N

Lee, M

Paizis, K

Abboud, A

Manning, J A

Mount, P F

Power, D A

NEDD4L

Pre-eclampsia

epithelial sodium channel

ubiquitin ligase

urinary extracellular vesicles

Journal Article

0000-0002-3736-0777

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10.1080/10641955.2023.2232029

To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n = 20). UEV were separated by differential ultracentrifugation. NEDD4L, α-ENaC and γ-ENaC were identified by immunoblotting. There was no difference in the expression of NEDD4L (p = 0.17) and α-ENaC (p = 0.10). PE subjects showed increased expression of γ-ENaC by 6.9-fold compared to NP (p < 0.0001). ENaC expression is upregulated in UEV of pre-eclamptic subjects but was not associated with changes in NEDD4L.

link

Hypertension in Pregnancy 2023-12; 42(1)

Hypertension in Pregnancy

1525-6065