Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33175
Title: COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study.
Austin Authors: Hall, Victoria G;Sim, Beatrice Z;Lim, Chhay;Hocking, Christopher;Teo, Teddy;Runnegar, Naomi;Boan, Peter;Heath, Christopher H;Rainey, Natalie;Lyle, Megan;Steer, Christopher;Liu, Eunice;Doig, Cassandra;Drummond, Kate;Charles, Patrick G P ;See, Katharine;Lim, Lyn-Li;Shum, Omar;Bak, Narin;Mclachlan, Sue-Anne;Singh, Kasha P;Laundy, Nicholas;Gallagher, Jenny;Stewart, Marcelle;Saunders, Natalie R;Klimevski, Emily;Demajo, Jessica;Reynolds, Gemma;Thursky, Karin A;Worth, Leon J;Spelman, Timothy;Yong, Michelle K;Slavin, Monica A;Teh, Benjamin W
Affiliation: Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia
Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Australia.
Department of Oncology, Lyell McEwin Hospital, Adelaide, South Australia, Australia.
Department of Infectious Diseases, Lyell McEwin Hospital, Adelaide, South Australia, Australia.
Department of Infectious Diseases, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Department of Microbiology, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.
Department of Cancer Services, Cairns Hospital, Cairns, Queensland, Australia.
Border Medical Oncology, Albury Wodonga Regional Cancer Centre, Albury, NSW, Australia.
Department of Infectious Diseases, Royal North Shore Hospital, Sydney, NSW, Australia.
Infectious Diseases
Department of Respiratory, Northern Hospital, Epping, VIC, Australia.
Monash University, Eastern Health Clinical School, Box Hill, VIC, Australia.
Department of Infectious Diseases, Wollongong Hospital, Wollongong, NSW, Australia.
Department of Infectious Diseases, Royal Adelaide Hospital, Adelaide, SA, Australia.
Department of Oncology, St Vincent's Hospital, Fitzroy, VIC, Australia.
Department of Infectious Diseases, Peninsula Health, Frankston, VIC, Australia.
Department of Medicine, University of Melbourne, Parkville, VIC, Australia.
.
Department of Biostatistics and Epidemiology, Peter MacCallum Cancer Centre, VIC, Australia.;Centre for Population Health, Burnet Institute, Melbourne, VIC, Australia.
Department of Infectious Diseases, Royal Melbourne Hospital, Parkville, VIC, Australia.
Issue Date: 19-Jun-2023
Date: 2023
Publication information: The Lancet Regional Health. Western Pacific 2023
Abstract: The global COVID-19 pandemic disproportionately affected certain populations and its management differed between countries. This national study describes characteristics and outcomes of COVID-19 in patients with cancer in Australia. We performed a multicentre cohort study of patients with cancer and COVID-19 from March 2020 to April 2022. Data were analysed to determine varying characteristics between cancer types and changes in outcomes over time. Multivariable analysis was performed to determine risk factors associated with oxygen requirement. 620 patients with cancer from 15 hospitals had confirmed COVID-19. There were 314/620 (50.6%) male patients, median age 63.5 years (IQR 50-72) and majority had solid organ tumours (392/620, 63.2%). The rate of COVID-19 vaccination (≥1 dose) was 73.4% (455/620). Time from symptom onset to diagnosis was median 1 day (IQR 0-3), patients with haematological malignancy had a longer duration of test positivity. Over the study period, there was a significant decline in COVID-19 severity. Risk factors associated with oxygen requirement included male sex (OR 2.34, 95% CI 1.30-4.20, p = 0.004), age (OR 1.03, 95% CI 1.01-1.06, p = 0.005); not receiving early outpatient therapy (OR 2.78, 95% CI 1.41-5.50, p = 0.003). Diagnosis during the omicron wave was associated with lower odds of oxygen requirement (OR 0.24, 95% CI 0.13-0.43, p < 0.0001). Outcomes from COVID-19 in patients with cancer in Australia over the pandemic have improved, potentially related to changing viral strain and outpatient therapies. This study was supported by research funding from MSD.
URI: https://ahro.austin.org.au/austinjspui/handle/1/33175
DOI: 10.1016/j.lanwpc.2023.100824
ORCID: 
Journal: The Lancet Regional Health. Western Pacific
Start page: 100824
PubMed URL: 37360862
ISSN: 2666-6065
Type: Journal Article
Subjects: COVID-19
Severity
Treatment
Vaccination
Appears in Collections:Journal articles

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