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Title: Hemoperfusion and Immunomodulation.
Austin Authors: Ronco, Claudio;Samoni, Sara;Bellomo, Rinaldo 
Affiliation: International Renal Research Institute of Vicenza (IRRV), Vicenza, Italy
Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Critical Care, University of Melbourne, Melbourne, Victoria, Australia
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.
Department of Medicine, University of Padova, Padova, Italy
Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia
Data Analytics Research and Evaluation (DARE) Centre
Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Intensive Care
Issue Date: 1-Jun-2023
Date: 2023
Publication information: Contributions to Nephrology 2023
Abstract: Recent development in sorbent technology has spurred new interest in the potential of hemoperfusion (HP) in clinical conditions such as cytokine release syndromes and sepsis. Although the role of nonselective HP in such conditions requires solid evidence and more studies, the rationale for clinical application is clearly emerging. Greater biocompatibility and safety of the new sorbents may allow easy and safe application of HP in those conditions where the innate and the adaptive immune response of the individual appears to be dysregulated. Recent results in small studies seem to confirm the plausibility for this therapeutic approach. The concept suggested by the peak concentration hypothesis justifies new studies and the application of HP in selected patients to remove the peaks of circulating mediators responsible for conditions of hyperinflammation or immunodepression.
DOI: 10.1159/000529885
Journal: Contributions to Nephrology
Start page: 1
End page: 7
PubMed URL: 37263236
ISSN: 1662-2782
Type: Journal Article
Appears in Collections:Journal articles

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