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Title: | Immuno-oncology therapy associated thromboembolic events in metastatic renal cell carcinoma. | Austin Authors: | Alhamdani, Zein;Alberto, Matthew;Ischia, Joseph J | Affiliation: | Surgery (University of Melbourne) | Issue Date: | Jul-2023 | Date: | 2023 | Publication information: | Urology Case Reports 2023-07; 49 | Abstract: | The relationship between thromboembolic events (TEs) and immune-oncology (IO) agents in patients with metastatic renal cell carcinoma (mRCC) with inferior-vena-cava (IVC) thrombus has not been explored despite conferring significant morbidity. A late 30s female is diagnosed with mRCC with a level-II IVC thrombus after presenting with back pain. Two weeks post initiation of immunotherapy, she re-presented with bilateral sub-massive pulmonary emboli requiring IVC and pulmonary thrombectomy. This case exposes a potential relationship between mRCC and IVC thrombus with IO agents that creates a critically hypercoagulable state. This issue requires further investigation given the apparent under-reporting of TEs in these patients. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/32984 | DOI: | 10.1016/j.eucr.2023.102420 | ORCID: | Journal: | Urology Case Reports | Start page: | 102420 | PubMed URL: | 37215941 | Type: | Journal Article | Subjects: | Case report IVC thrombus Immune-oncology Immunotherapy Metastatic renal cell carcinoma Pulmonary embolism Thromboembolic |
Appears in Collections: | Journal articles |
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