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Title: Immuno-oncology therapy associated thromboembolic events in metastatic renal cell carcinoma.
Austin Authors: Alhamdani, Zein;Alberto, Matthew;Ischia, Joseph J 
Affiliation: Surgery (University of Melbourne)
Issue Date: Jul-2023
Date: 2023
Publication information: Urology Case Reports 2023-07; 49
Abstract: The relationship between thromboembolic events (TEs) and immune-oncology (IO) agents in patients with metastatic renal cell carcinoma (mRCC) with inferior-vena-cava (IVC) thrombus has not been explored despite conferring significant morbidity. A late 30s female is diagnosed with mRCC with a level-II IVC thrombus after presenting with back pain. Two weeks post initiation of immunotherapy, she re-presented with bilateral sub-massive pulmonary emboli requiring IVC and pulmonary thrombectomy. This case exposes a potential relationship between mRCC and IVC thrombus with IO agents that creates a critically hypercoagulable state. This issue requires further investigation given the apparent under-reporting of TEs in these patients.
DOI: 10.1016/j.eucr.2023.102420
Journal: Urology Case Reports
Start page: 102420
PubMed URL: 37215941
Type: Journal Article
Subjects: Case report
IVC thrombus
Metastatic renal cell carcinoma
Pulmonary embolism
Appears in Collections:Journal articles

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