Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32981
Title: Targeting the BRAF pathway in haematological diseases.
Austin Authors: Rees, Matthew J ;Dickinson, Michael;Paterson, James;Ng, Teng F;Grigg, Andrew P ;Moore, John;Blombery, Piers;Seymour, John F
Affiliation: Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Department of Clinical Haematology, St Vincent's Hospital, Sydney, New South Wales, Australia.
Department of Clinical Haematology, Gold Coast University Hospital, Gold Coast, Queensland, Australia.
Clinical Haematology
Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia.;Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia.;Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Issue Date: May-2023
Publication information: Internal Medicine Journal 2023
Abstract: Since the recognition of BRAF V600E mutations in the majority of cases of hairy cell leukaemia, Erdheim-Chester disease and Langerhans cell histiocytosis, the targeted oral kinase inhibitors dabrafenib and vemurafenib have been adapted for their treatment. Like other targeted agents, these drugs produce high response rates and predictable but unique side effects. Physician familiarity is essential for the effective use of these agents. We review the Australian experience of BRAF/MEK inhibitor therapy in these rare haematological cancers.
URI: https://ahro.austin.org.au/austinjspui/handle/1/32981
DOI: 10.1111/imj.16091
ORCID: 0000-0001-8360-2952
0000-0002-1492-5966
Journal: Internal Medicine Journal
Start page: 845
End page: 849
PubMed URL: 37222093
ISSN: 1445-5994
Type: Journal Article
Appears in Collections:Journal articles

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