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Title: Associations of Enlarged Perivascular Spaces With Brain Lesions, Brain Age, and Clinical Outcomes in Chronic Traumatic Brain Injury.
Austin Authors: Hicks, Amelia;Sinclair, Benjamin;Shultz, Sandy;Pham, William;Silbert, Lisa C;Schwartz, Daniel L;Rowe, Christopher C ;Ponsford, Jennie L;Law, Meng;Spitz, Gershon
Affiliation: Monash-Epworth Rehabilitation Research Centre, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, 3168, Australia
Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.
Health and Human Services, Vancouver Island University, Nanaimo BC, Canada
Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, 3010, Australia.
Department of Neurology; Portland Veterans Affairs Health Care System, Portland, OR, USA.
NIA-Layton Oregon Aging & Alzheimer's Disease Research Center; Oregon Health & Science University, Portland, OR, USA.
Molecular Imaging and Therapy
Department of Radiology, Alfred Health, Melbourne 3004, Australia.
Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
Department of Neurology, Alfred Health, Melbourne 3004, Australia.
Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA.
Issue Date: 4-Jul-2023
Date: 2023
Publication information: Neurology 2023; 101(1)
Abstract: Enlarged perivascular spaces (ePVS) have been identified as a key signature of glymphatic system dysfunction in neurological conditions. The incidence and clinical implications of ePVS after traumatic brain injury (TBI) are not yet understood. We investigated whether individuals with chronic moderate-severe TBI had an increased burden of ePVS, and whether ePVS burden is modulated by the presence of focal lesions, older brain age, and poorer sleep quality. We examined whether increased burden of ePVS was associated with poorer cognitive and emotional outcomes. Using a cross-sectional design, participants with a single moderate-severe chronic TBI (sustained ≥ 10 years ago) were recruited from an inpatient rehabilitation program. Control participants were recruited from the community. Participants underwent 3T brain MRI, neuropsychological assessment, and clinical evaluations. ePVS burden in white matter was quantified using automated segmentation. The relationship between number of ePVS, group membership, focal lesions, brain age, current sleep quality, and outcome was modelled using negative binomial and linear regressions. This study included 100 participants with TBI (70% male; M = 56.8 years), and 75 control participants (54.3% male; M = 59.8 years). The TBI group had a significantly greater burden of ePVS (prevalence ratio rate (PRR) = 1.29, p = 0.013, CI95% [1.05, 1.57]). The presence of bilateral lesions was associated with greater ePVS burden (PRR = 1.41, p = 0.021, CI95% [1.05, 1.90]). There was no association between ePVS burden, sleep quality (PRR = 1.01, p = 0.491, CI95% [0.98, 1.048]) and sleep duration (PRR = 1.03, p = 0.556, CI95% [0.92, 1.16]). ePVS was associated with verbal memory (β = -0.42, p = 0.006, CI95% [-0.72, -0.12]), but not with other cognitive domains. Burden of ePVS was not associated with emotional distress (β = -0.70, p = 0.461, CI95% [-2.57, 1.17) or brain age (PRR = 1.00, p = 0.665, CI95% [0.99, 1.02]). TBI is associated with a greater burden of ePVS, especially when there have been bilateral brain lesions. ePVS was associated with reduced verbal memory performance. ePVS may indicate ongoing impairments in glymphatic system function in the chronic post-injury period.
DOI: 10.1212/WNL.0000000000207370
ORCID: 0000-0002-1152-0576
Journal: Neurology
PubMed URL: 37156615
ISSN: 1526-632X
Type: Journal Article
Appears in Collections:Journal articles

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