Austin Health

Title
Challenges of Glycemic Control in People With Diabetes and Advanced Kidney Disease and the Potential of Automated Insulin Delivery.
Publication Date
2023-05-10
Author(s)
Lu, Jean C
Lee, Petrova
Ierino, Francesco
MacIsaac, Richard J
Ekinci, Elif I
O'Neal, David
Subject
artificial pancreas
automated insulin delivery
chronic kidney disease
diabetes
dialysis
insulin pump
Type of document
Journal Article
OrcId
0000-0002-3151-232X
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#PLACEHOLDER_PARENT_METADATA_VALUE#
0000-0002-0870-4032
DOI
10.1177/19322968231174040
Abstract
Diabetes is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease in the world. It is known that maintaining optimal glycemic control can slow the progression of CKD. However, the failing kidney impacts glucose and insulin metabolism and contributes to increased glucose variability. Conventional methods of insulin delivery are not well equipped to adapt to this increased glycemic lability. Automated insulin delivery (AID) has been established as an effective treatment in patients with type 1 diabetes mellitus, and there is emerging evidence for their use in type 2 diabetes mellitus. However, few studies have examined their role in diabetes with concurrent advanced CKD. We discuss the potential benefits and challenges of AID use in patients with diabetes and advanced CKD, including those on dialysis.
Link
Citation
Journal of Diabetes Science and Technology 2023
Jornal Title
Journal of Diabetes Science and Technology
ISSN
1932-2968

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