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Title: The characteristics of SARS-CoV-2-positive children in Australian hospitals: a PREDICT network study.
Austin Authors: Ibrahim, Laila;Wilson, Catherine;Tham, Doris;Corden, Mark;Jani, Shefali;Zhang, Michael;Kochar, Amit;Tan, Ker Fern;George, Shane;Phillips, Natalie T;Buntine, Paul;Robins-Browne, Karen;Chong, Vimuthi;Georgeson, Thomas;Lithgow, Anna;Davidson, Sarah;O'Brien, Sharon;Tran, Viet;Babl, Franz E
Affiliation: Royal Children's Hospital, Melbourne, Melbourne, VIC.
Murdoch Children's Research Institute, Melbourne, VIC.
Western Health, Melbourne, VIC.
Northern Hospital Epping, Melbourne, VIC.
The Children's Hospital at Westmead, Sydney, NSW.;The Children's Hospital at Westmead Clinical School, the University of Sydney, Sydney, NSW.
John Hunter Hospital, Newcastle, NSW.
Women's and Children's Hospital, Adelaide, SA.
Auburn Hospital, Sydney, NSW.;University of Notre Dame, Sydney, NSW.
Gold Coast University Hospital, Gold Coast, QLD.;Child Health Research Centre, the University of Queensland, Brisbane, QLD.
Child Health Research Centre, the University of Queensland, Brisbane, QLD.;Queensland Children's Hospital, Brisbane, QLD.
Eastern Health, Melbourne, VIC.;Eastern Health Clinical School, Monash University, Melbourne, VIC.
University Hospital Geelong, Geelong, VIC.
Austin Health
Canberra Hospital, Canberra, ACT.
Royal Darwin and Palmerston Hospital, Darwin, NT.
Sunshine Coast University Hospital, Sunshine Coast, QLD.
Perth Children's Hospital, Perth, WA.;Curtin University, Perth, WA.
Royal Hobart Hospital, Hobart, TAS.;Tasmanian School of Medicine, University of Tasmania, Hobart, TAS.
Murdoch Children's Research Institute, Melbourne, VIC.;The University of Melbourne, Melbourne, VIC.
PREDICT Research Network, Melbourne, VIC.
Issue Date: 5-Jun-2023
Date: 2023
Publication information: The Medical Journal of Australia 2023; 218(10)
Abstract: To examine the clinical characteristics and short term outcomes for children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections who presented to Australian hospitals during 2020 and 2021. Retrospective case review study in nineteen hospitals of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network from all Australian states and territories, including seven major paediatric tertiary centres and eight Victorian hospitals. SARS-CoV-2-positive people under 18 years of age who attended emergency departments or were admitted to hospital during 1 February 2020 - 31 December 2021. Epidemiological and clinical characteristics, by hospital care type (emergency department [ED] or inpatient care). A total of 1193 SARS-CoV-2-positive children and adolescents (527 girls, 44%) attended the participating hospitals (107 in 2020, 1086 in 2021). Their median age was 3.8 years (interquartile range [IQR], 0.8-11.4 years); 63 were Aboriginal or Torres Strait Islander people (5%). Other medical conditions were recorded for 293 children (25%), including asthma (86, 7%) and premature birth (68, 6%). Medical interventions were not required during 795 of 1181 ED presentations (67%); children were discharged directly home in 764 cases (65%) and admitted to hospital in 282 (24%; sixteen to intensive care units). The 384 admissions to hospital (including 102 direct admissions) of 341 children (25 infants under one month of age) included 23 to intensive care (6%); the median length of stay was three days (IQR, 1-9 days). Medical interventions were not required during 261 admissions (68%); 44 children received respiratory support (11%) and 21 COVID-19-specific treatments, including antiviral and biologic agents (5%). Being under three months of age (v one year to less than six years: odds ratio [OR], 2.6; 95% confidence interval [CI], 1.7-4.0) and pre-existing medical conditions (OR, 2.5; 95% CI, 1.9-3.2) were the major predictors of hospital admission. Two children died, including one without a known pre-existing medical condition. During 2020 and 2021, most SARS-CoV-2-positive children and adolescents who presented to participating hospitals could be managed as outpatients. Outcomes were generally good, including for those admitted to hospital.
DOI: 10.5694/mja2.51934
ORCID: 0000-0001-9267-9812
Journal: The Medical Journal of Australia
PubMed URL: 37087105
ISSN: 1326-5377
Type: Journal Article
Subjects: COVID-19
Emergency treatment
Appears in Collections:Journal articles

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