Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32751
Title: Specific fetal malformations following intrauterine exposure to antiseizure medication.
Austin Authors: Vajda, Frank;O'Brien, Terence;Graham, Janet;Hitchcock, Alison;Perucca, Piero ;Lander, Cecilie;Eadie, Mervyn
Affiliation: Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia.
Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia.
Medicine (University of Melbourne)
Comprehensive Epilepsy Program
Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia.
Issue Date: 21-Apr-2023
Date: 2023
Publication information: Epilepsy & Behavior : E&B 2023; 142
Abstract: To investigate in the Australian Pregnancy Register of Antiepileptic Drugs patterns of fetal malformation associated with intrauterine exposure to particular currently available antiseizure medications taken by women with epilepsy. There was statistically significant evidence (P < 0.05) of an increased hazard of fetal malformation associated with exposure to valproate, carbamazepine, topiramate, zonisamide, and with conception after assisted fertilization, but a reduced hazard in the offspring of women who continued to smoke during pregnancy. Valproate exposure was associated with malformations in a wide range of organs and organ systems, carbamazepine and topiramate with hydronephrosis, topiramate also with hypospadias, zonisamide with spina bifida and assisted fertilization with heart and great vessel maldevelopment. Prenatal valproate exposure appears to interfere with the development of many if not all, fetal tissues. It seems likely that prenatal exposure to carbamazepine and topiramate, and possibly exposure to zonisamide, but also some process related to in vitro fertilization, may more selectively affect the normal development of particular fetal tissues or organs.
URI: https://ahro.austin.org.au/austinjspui/handle/1/32751
DOI: 10.1016/j.yebeh.2023.109219
ORCID: 
Journal: Epilepsy & Behavior : E&B
Start page: 109219
PubMed URL: 37088066
ISSN: 1525-5069
Type: Journal Article
Subjects: Antiseizure medication
Assisted fertilization
Smoking
Specific malformation
Teratogenesis
Valproate
Appears in Collections:Journal articles

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