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Title: Approach to the patient: the evaluation and management of men ≥ 50 years with a low serum testosterone concentration.
Austin Authors: Grossmann, Mathis ;Jayasena, Channa N;Anawalt, Bradley D
Affiliation: Medicine (University of Melbourne)
Section of Investigative Medicine, Imperial College London, UK.
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States.
Issue Date: 30-Mar-2023
Date: 2023
Publication information: The Journal of Clinical Endocrinology and Metabolism 2023 -08-18; 108(9)
Abstract: Although testosterone replacement in men with classic hypogonadism due to an identified pathology of the hypothalamic-pituitary-testicular axis is uncontroversial, the role of testosterone treatment for men with age-related declines in circulating testosterone is unclear. This is due to the lack of large, long-term testosterone therapy trials assessing definitive clinical endpoints. However, men >50 years, particularly those who have a body mass index >25 kg/m2 and multiple co-morbidities, commonly present with clinical features of androgen deficiency and low serum testosterone concentrations. Clinicians are faced with the question whether to initiate testosterone therapy, a difficult dilemma that entails a benefit-risk analysis with limited evidence from clinical trials. Using a case scenario, we present a practical approach to the clinical assessment and management of such men.
DOI: 10.1210/clinem/dgad180
ORCID: 0000-0001-8261-3457
Journal: The Journal of Clinical Endocrinology and Metabolism
PubMed URL: 36995891
ISSN: 1945-7197
Type: Journal Article
Subjects: aging men
androgen deficiency
testosterone therapy
Appears in Collections:Journal articles

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