Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32374
Title: Clinical characteristics of Australian treatment-naïve patients with classical Hodgkin lymphoma from the lymphoma and related diseases registry.
Austin Authors: Nguyen, James;Wellard, Cameron;Chung, Eliza;Cheah, Chan Y;Dickinson, Michael;Doo, Nicole Wong;Keane, Colm;Talaulikar, Dipti;Berkahn, Leanne;Morgan, Susan;Hamad, Nada;Cochrane, Tara;Johnston, Anna M;Forsyth, Cecily;Opat, Stephen;Barraclough, Allison ;Mutsando, Howard;Ratnasingam, Sumita;Giri, Pratyush;Wood, Erica M;McQuilten, Zoe K;Hawkes, Eliza A 
Affiliation: Eastern Health, Melbourne, Victoria, Australia.
Monash University School of Public Health & Preventive Medicine, Melbourne, Victoria, Australia.
Monash University School of Public Health & Preventive Medicine, Melbourne, Victoria, Australia.
Sir Charles Gairdner Hospital and Medical School, University of Western Australia, Western Australia, Australia.
Peter MacCallum Cancer Centre; Royal Melbourne Hospital, and the Sir Peter MacCallum Department of Oncology at the University of Melbourne, Melbourne, Victoria, Australia.
Concord Repatriation General Hospital; Concord Clinical School, University of Sydney, Concord, New South Wales, Australia.
Princess Alexandra Hospital, Queensland, Australia.
Canberra Health Services, The Australian National University, Australian Capital Territory, Australia.
Auckland City Hospital, Auckland, New Zealand.
Alfred Health, Melbourne, Victoria, Australia.
St Vincent's Hospital Sydney, Sydney, New South Wales, Australia.
Gold Coast University Hospital, Griffith University, Southport, Queensland, Australia.
Royal Hobart Hospital, Tasmania, Australia.
Gosford Hospital, New South Wales, Australia.
Monash Health, Victoria, Australia.
Fiona Stanley Hospital, Western Australia, Australia.
Toowoomba Hospital, Queensland, Australia.
University Hospital Geelong, Victoria, Australia.
Royal Adelaide Hospital, South Australia, Australia.
Monash University School of Public Health & Preventive Medicine, Melbourne, Victoria, Australia.
Monash University School of Public Health & Preventive Medicine, Melbourne, Victoria, Australia.
Monash University School of Public Health & Preventive Medicine, Melbourne, Victoria, Australia.
Olivia Newton-John Cancer Research Institute
Issue Date: Apr-2023
Date: 2022
Publication information: European journal of haematology 2023; 110(4)
Abstract: Comprehensive clinical characteristics of Australian patients with classical Hodgkin Lymphoma (cHL) have not previously been systematically collected and described. We report real-world data of 498 eligible patients from the first 5 years of the Lymphoma and Related Diseases Registry (LaRDR), including baseline characteristics, histologic subtype, and treatment patterns in first-line therapy. Patient demographics and distribution of histopathological subtypes of cHL are similar to reported international cohorts. Doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) was the most common therapy for both early and advanced-stage disease, and 48% of patients with the early-stage disease received radiotherapy. Treatment patterns are consistent with international guidelines. In comorbid patients ≥60 years of age with advanced-stage disease, there is greater variation in treatment. In patients with a recorded response, the objective response rate (ORR) was 96% in early-stage disease, and 88% in advanced-stage disease. Early progression-free survival data suggest Australian patients with cHL have good outcomes, similar to other international studies.
URI: https://ahro.austin.org.au/austinjspui/handle/1/32374
DOI: 10.1111/ejh.13915
ORCID: 0000-0003-3206-2188
0000-0001-7988-1565
0000-0002-1492-5966
0000-0003-3725-3397
0000-0002-2668-1399
0000-0001-5959-5203
0000-0003-1615-0540
0000-0001-7527-2340
0000-0001-9698-7185
0000-0002-0376-2559
Journal: European journal of haematology
Start page: 386
End page: 395
PubMed URL: 36539351
ISSN: 1600-0609
Type: Journal Article
Subjects: classical Hodgkin lymphoma
clinical characteristics
demographic
treatment regimen
Bleomycin/therapeutic use
Doxorubicin/therapeutic use
Vinblastine/therapeutic use
Dacarbazine/therapeutic use
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Appears in Collections:Journal articles

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