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Title: | Systematic Review of Cost-Effectiveness Analysis for Surgical and Neurostimulation Treatments for Drug-Resistant Epilepsy in Adults. | Austin Authors: | Kee, Nicholas Ngan;Foster, Emma;Marquina, Clara;Tan, Andy;Pang, Samantha S T;O'Brien, Terence J;Kwan, Patrick;Jackson, Graeme D ;Chen, Zhibin;Ademi, Zanfina | Affiliation: | The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia. Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3000, Australia. Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC 3800, Australia. Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC 3800, Australia. Department of Medicine, The University of Melbourne, Parkville, VIC 3050, Australia. Department of Medicine, The University of Melbourne, Parkville, VIC 3050, Australia. Department of Medicine, The University of Melbourne, Parkville, VIC 3050, Australia. Department of Medicine, The University of Melbourne, Parkville, VIC 3050, Australia. Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Neurology The Florey Institute of Neuroscience and Mental Health |
Issue Date: | 2-May-2023 | Date: | 2023 | Publication information: | Neurology 2023; 2023-05-02; 100(18) | Abstract: | Surgical and neurostimulator treatments are effective for reducing seizure burden in selected individuals living with drug resistant epilepsy (DRE). We aimed to determine the presence and key model determinants for cost-effectiveness of these interventions, compared to medical management alone, to assist with decisions about resource allocation. A systematic literature search was conducted on June 1, 2022, using Medline, Embase, NHS Economic Evaluation Database, and the Cost-Effectiveness Analysis database. Included studies were economic evaluations in adult DRE cohorts; comparing surgical and neurostimulator treatments (vagus nerve stimulation (VNS), responsive neurostimulation (RNS), and deep brain stimulation (DBS)) vs medical management alone; and reporting cost-benefit analysis, cost-utility, or cost-effectiveness. Exclusion criteria were studies with pediatric cohorts and those published in a language other than English. Three independent reviewers screened, extracted, and assessed data against the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist, and a fourth reviewer adjudicated discrepancies. Ten studies met inclusion criteria. Seven studies evaluated epilepsy surgery, and three evaluated neurostimulation treatments. All relevant studies established that epilepsy surgery is a cost-effective intervention compared to medical management alone, with regards to quality adjusted life years (QALYs), and seizure freedom at 2- and 5 years. All relevant studies found neurostimulator treatments to be potentially cost-effective. The incremental cost-effectiveness ratio (ICER), with lower ICER indicating greater cost-effectiveness, was reported for nine studies, and varied between GBP £3,013 and US $61,333. Cost adaptation revealed ICERs from US $170 to US $121,726. Key model determinants included, but were not limited to, improved surgical outcomes and quality of life, reduced surgical and presurgical evaluation costs, higher rates of surgical eligibility after referral and evaluation, epilepsy subtype, less expensive neurostimulator devices with improved longevity, and cost analysis strategy used in the analysis. There is consistent evidence that epilepsy surgery is a cost-effective treatment for eligible candidates with DRE. Limited evidence suggests that VNS, RNS, and DBS may be cost-effective therapies for DRE, although more health economic evaluations alongside prospective clinical trials are needed to validate these findings. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/32354 | DOI: | 10.1212/WNL.0000000000207137 | ORCID: | 0000-0002-7917-5326 0000-0002-1888-6917 0000-0002-0625-3522 |
Journal: | Neurology | PubMed URL: | 36927880 | ISSN: | 1526-632X | Type: | Journal Article |
Appears in Collections: | Journal articles |
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