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Title: The effect of the AN69 ST100 versus oXiris® membrane on filter life during CRRT for non-anticoagulated liver failure patients.
Austin Authors: Naorungroj, Thummaporn ;Baldwin, Ian C ;Eastwood, Glenn M ;Bellomo, Rinaldo 
Affiliation: Intensive Care
Division of Intensive Care, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Data Analytics Research and Evaluation (DARE) Centre
Issue Date: 9-Mar-2023
Date: 2023
Publication information: The International journal of artificial organs 2023; 46(4)
Abstract: In patients with liver failure, continuous renal replacement therapy (CRRT) without anticoagulation may be necessary. A new heparin coated membrane (oXiris®) may prolong circuit life in this setting. In liver failure patients not receiving anticoagulation, to compare CRRT circuit life with the oXiris® versus the AN69 ST100 (usual care) membrane. Randomized single cross-over trial. We studied 20 patients and 39 circuits. Twenty-five treatments used femoral and 14 internal jugular access catheters. Median circuit life was 21 h (IQR: 8.25-35.5) with the AN69 versus 16.0 h (14-25) with the oXiris® membrane (p = 0.36). Median first circuit duration was 14 (11.25-23) h for the AN69 ST100 versus 16 (8 -26) for the oXiris® membrane. There was also no difference between the AN69 ST100 or oXiris® membrane circuits using femoral access at 13 (8 -22.5) versus 15.5 (12.5-21.5) h (p = 0.57) or internal jugular access at 28 (13-47) versus 23 (21-29) h (p = 0.79), respectively. The oXiris® heparin-grafted membrane does not appear to prolong circuit life in liver failure patients receiving CRRT without anticoagulation.
DOI: 10.1177/03913988231155253
ORCID: 0000-0001-6562-4891
Journal: The International Journal of Artificial Organs
Start page: 3913988231155253
PubMed URL: 36895128
ISSN: 1724-6040
Type: Journal Article
Subjects: Continuous renal replacement therapy
Intensive Care Unit
apheresis & detoxification techniques
artificial kidney
circuit life
liver failure
Appears in Collections:Journal articles

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