Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32272
Title: Tau, β-amyloid, and glucose metabolism following service-related Traumatic Brain Injury in Vietnam war veterans: The AIBL-VETS study.
Austin Authors: Cummins, Tia Louise;Doré, Vincent ;Feizpour, Azadeh;Krishnadas, Natasha ;Bourgeat, Pierrick;Elias, Alby;Lamb, Fiona ;Williams, Robert;Hopwood, Malcolm John;Landau, Susan;Villemagne, Victor L ;Weiner, Michael;Rowe, Christopher C 
Affiliation: Molecular Imaging and Therapy
The Florey Institute of Neuroscience and Mental Health
The Australian eHealth Research Centre, CSIRO, Brisbane, Queensland, Australia
Melbourne Brain Centre Imaging Unit, The University of Melbourne, Melbourne, Victoria, Australia.
Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; mhopwood@unimelb.edu.au.
Helen Wills Neuroscience Institute, 71433, Berkeley, California, United States; slandau@berkeley.edu.
University of California, San Francisco, California, United States; Michael.Weiner@ucsf.edu.
Issue Date: 28-Feb-2023
Date: 2023
Publication information: Journal of Neurotrauma 2023, 40(11-12)
Abstract: Traumatic Brain Injury (TBI) is common amongst military veterans and has been associated with an increased risk of dementia. It is unclear if this is due to increased risk for Alzheimer's disease (AD) or other mechanisms. This case control study sought evidence for AD, as defined by the 2018 NIA-AA research framework, by measuring tau, β-amyloid and glucose metabolism using positron emission tomography (PET) in veterans with service-related TBI. Seventy male Vietnam war veterans - 40 with TBI (aged 68.0±2.5 years) and 30 controls (aged 70.1±5.3 years) - with no prior diagnosis of dementia or mild cognitive impairment underwent β-amyloid (18F-Florbetaben), tau (18F-Flortaucipir) and 18F-FDG PET. The TBI cohort included 15 participants with mild, 16 with moderate, and 9 with severe injury. β-amyloid level was calculated using the Centiloid (CL) method and tau was measured by Standardized Uptake Value Ratios (SUVR) using the cerebellar cortex as reference region. Analyses were adjusted for age and APOE-e4. The findings were validated in an independent cohort from the ADNI-DOD study. There were no significant nor trending differences in β-amyloid or tau levels or 18F-FDG uptake between the TBI and control groups before and after controlling for covariates. The β-amyloid and tau findings were replicated in the ADNI-DOD validation cohort and persisted when the AIBL-VETS and ADNI-DOD cohorts were combined (114 TBI vs 87 controls in total). In conclusion, no increase in the later life accumulation of the neuropathological markers of AD in veterans with a remote history of TBI was identified.
URI: https://ahro.austin.org.au/austinjspui/handle/1/32272
DOI: 10.1089/neu.2022.0172
ORCID: 
Journal: Journal of Neurotrauma
PubMed URL: 36855333
ISSN: 1557-9042
Type: Journal Article
Subjects: BETA AMYLOID
BIOMARKERS
NEURODEGENERATIVE DISORDERS
PET SCANNING
TRAUMATIC BRAIN INJURY
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