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Title: | Dearth of ICD Codes for Complications of Immune Checkpoint Inhibitors Impedes Clinical Care and Research. | Austin Authors: | Cheung, Yee-Ming Melody ;Hamnvik, Ole-Petter R;Shariff, Afreen;Gallagher, Emily J | Affiliation: | Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA. Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Duke University School of Medicine, Durham, NC 27708, USA. Medicine (University of Melbourne) |
Issue Date: | 9-Feb-2023 | Date: | 2023 | Publication information: | Journal of the Endocrine Society 2023; 7(4) | Abstract: | Immune checkpoint inhibitors (ICIs) are a rapidly expanding class of targeted therapies effective in the treatment of various cancers. However, while efficacious, ICIs have been associated with treatment complications, namely immune-related adverse events (irAEs). IrAEs of the endocrine system are among the most commonly reported irAEs, but despite their high incidence, standardized disease definitions and endocrine IrAE-specific International Classification of Diseases (ICD) codes remain lacking. This dearth of standardized nomenclature and ICD codes has in many ways impeded both the clinical care of patients and the progress of endocrine irAE-related research. ICD codes are used internationally and are essential for medical claims reporting in the health care setting, and they provide a universal language system for recording, reporting, and monitoring diseases. These codes are also a well-accepted form of electronic health record data capture that facilitates the collection, storage, and sharing of data. Therefore, the lack of standardized disease definitions and ICD codes has been associated with misclassification and suboptimal management of individuals with endocrine irAEs and has also been associated with reduced data availability, comparability, and quality. Harmonized and clinically relevant disease definitions along with the subsequent development of endocrine-irAE-specific ICD codes will provide a systematic approach to understanding the spectrum and burden of endocrine irAE diseases, and will have a positive effect across clinical, public health, and research settings. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/32210 | DOI: | 10.1210/jendso/bvad019 | ORCID: | 0000-0002-7920-8474 | Journal: | Journal of the Endocrine Society | Start page: | bvad019 | PubMed URL: | 36819460 | ISSN: | 2472-1972 | Type: | Journal Article | Subjects: | endocrine immune-related adverse effects immune checkpoint inhibitors immunotherapy international classification of disease nomenclature |
Appears in Collections: | Journal articles |
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