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Title: Study protocol for PREPARE: a phase II feasibility/safety randomised controlled trial on PeRiopErative Penicillin AlleRgy TEsting.
Austin Authors: De Luca, Joseph F;James, Fiona L ;Vogrin, Sara;Chua, Kyra Y L ;Fletcher, Luke R ;Nazareth, Justin;Guha, Ranjan;Hardidge, Andrew J ;Douglas, Ned;Carruthers, John;Stewardson, Andrew;Cheng, Allen C;Johnson, Douglas;Douglass, Jo;Peel, Trisha;Trubiano, Jason 
Affiliation: Infectious Diseases
St Vincent's Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia.
Orthopaedic Surgery
Department of Anaesthesia, Melbourne Health, Parkville, Victoria, Australia.
Department of Anaesthesia, Alfred Health, Melbourne, Victoria, Australia.
Infectious Diseases, Alfred Health, Melbourne, Victoria, Australia.
Department of General Medicine, Melbourne Health, Parkville, Victoria, Australia.
Department of Medicine RMH, The University of Melbourne, Parkville, Victoria, Australia.
Infectious Diseases, Monash University, Melbourne, Victoria, Australia.
Issue Date: 24-Feb-2023
Date: 2023
Publication information: BMJ 2023; 13(2):e067653
Abstract: Patient-reported antibiotic allergy labels (AALs) are common. These labels have been demonstrated to have a negative impact on use of appropriate antibiotics and patient-related health outcomes. These patients are more likely to receive suboptimal antibiotics, have increased rates of surgical site infections and are more likely to be colonised with multidrug-resistant organisms. Increasing recognition that antibiotic allergy forms a key part of good antimicrobial stewardship has led to calls for greater access to antibiotic allergy assessment.PREPARE is a pilot randomised controlled trial of beta-lactam allergy assessment and point of care delabelling in perioperative patients utilising a validated antibiotic allergy assessment tool that has been repurposed into a smartphone application. The aim of the study is to assess the feasibility and safety of this approach in the perioperative outpatient setting.
DOI: 10.1136/bmjopen-2022-067653
ORCID: 0000-0001-6541-5512
Journal: BMJ
Start page: e067653
PubMed URL: 36828661
ISSN: 2044-6055
Type: Journal Article
Subjects: adult anaesthesia
adult surgery
infection control
Anti-Bacterial Agents/therapeutic use
Drug Hypersensitivity/drug therapy
Hypersensitivity/drug therapy
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