Study protocol for PREPARE: a phase II feasibility/safety randomised controlled trial on PeRiopErative Penicillin AlleRgy TEsting.

2023-02-24

De Luca, Joseph F

James, Fiona L

Vogrin, Sara

Chua, Kyra Y L

Fletcher, Luke R

Nazareth, Justin

Guha, Ranjan

Hardidge, Andrew J

Douglas, Ned

Carruthers, John

Stewardson, Andrew

Cheng, Allen C

Johnson, Douglas

Douglass, Jo

Peel, Trisha

Trubiano, Jason

adult anaesthesia

adult surgery

allergy

immunology

infection control

Journal Article

0000-0001-6541-5512

0000-0003-0469-5666

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0000-0002-5111-6367

10.1136/bmjopen-2022-067653

Patient-reported antibiotic allergy labels (AALs) are common. These labels have been demonstrated to have a negative impact on use of appropriate antibiotics and patient-related health outcomes. These patients are more likely to receive suboptimal antibiotics, have increased rates of surgical site infections and are more likely to be colonised with multidrug-resistant organisms. Increasing recognition that antibiotic allergy forms a key part of good antimicrobial stewardship has led to calls for greater access to antibiotic allergy assessment.PREPARE is a pilot randomised controlled trial of beta-lactam allergy assessment and point of care delabelling in perioperative patients utilising a validated antibiotic allergy assessment tool that has been repurposed into a smartphone application. The aim of the study is to assess the feasibility and safety of this approach in the perioperative outpatient setting.

link

BMJ 2023; 13(2):e067653

BMJ

2044-6055