Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease.

Chatterjee, Pratishtha; Doré, Vincent; Pedrini, Steve; Krishnadas, Natasha; Thota, Rohith; Bourgeat, Pierrick; Ikonomovic, Milos D; Rainey-Smith, Stephanie R; Burnham, Samantha C; Fowler, Christopher; Taddei, Kevin; Mulligan, Rachel S; Ames, David; Masters, Colin L; Fripp, Jürgen; Rowe, Christopher C; Martins, Ralph N; Villemagne, Victor L

doi:10.3233/JAD-220908

Title

Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease.

Publication Date

2023-02-09

Author(s)

Chatterjee, Pratishtha

Doré, Vincent

Pedrini, Steve

Krishnadas, Natasha

Thota, Rohith

Bourgeat, Pierrick

Ikonomovic, Milos D

Rainey-Smith, Stephanie R

Burnham, Samantha C

Fowler, Christopher

Taddei, Kevin

Mulligan, Rachel S

Ames, David

Masters, Colin L

Fripp, Jürgen

Rowe, Christopher C

Martins, Ralph N

Villemagne, Victor L

Subject

18F-SMBT-1

Astrocyte reactivity

biomarkers

glial fibrillary acidic protein

monoamine oxidase B

positron emission tomography

Type of document

Journal Article

OrcId

#PLACEHOLDER_PARENT_METADATA_VALUE#

DOI

10.3233/JAD-220908

Abstract

Astrocyte reactivity is an early event along the Alzheimer's disease (AD) continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity, is elevated across the AD continuum from preclinical to dementia stages. Monoamine oxidase-B (MAO-B) is also elevated in reactive astrocytes observed using 18F-SMBT-1 PET in AD.

Link

link

Citation

Journal of Alzheimer's disease : JAD 2023; 92(2)

Jornal Title

Journal of Alzheimer's Disease

ISSN

1875-8908

Austin Health

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