Please use this identifier to cite or link to this item:
Title: A review of diffusion-weighted magnetic resonance imaging in head and neck cancer patients for treatment evaluation and prediction of radiation-induced xerostomia.
Austin Authors: Ermongkonchai, Tai;Khor, Richard ;Wada, Morikatsu ;Lau, Eddie ;Xing, Daniel T ;Ng, Sweet Ping 
Affiliation: Radiation Oncology
Olivia Newton-John Cancer Wellness and Research Centre
Issue Date: 30-Jan-2023 2023
Publication information: Radiation Oncology (London, England) 2023; 18(1)
Abstract: The incidence of head and neck cancers (HNC) is rising worldwide especially with HPV-related oropharynx squamous cell carcinoma. The standard of care for the majority of patients with locally advanced pharyngeal disease is curative-intent radiotherapy (RT) with or without concurrent chemotherapy. RT-related toxicities remain a concern due to the close proximity of critical structures to the tumour, with xerostomia inflicting the most quality-of-life burden. Thus, there is a paradigm shift towards research exploring the use of imaging biomarkers in predicting treatment outcomes. Diffusion-weighted imaging (DWI) is a functional MRI feature of interest, as it quantifies cellular changes through computation of apparent diffusion coefficient (ADC) values. DWI has been used in differentiating HNC lesions from benign tissues, and ADC analyses can be done to evaluate tumour responses to RT. It is also useful in healthy tissues to identify the heterogeneity and physiological changes of salivary glands to better understand the inter-individual differences in xerostomia severity. Additionally, DWI is utilised in irradiated salivary glands to produce ADC changes that correlate to clinical xerostomia. The implementation of DWI into multi-modal imaging can help form prognostic models that identify patients at risk of severe xerostomia, and thus guide timely interventions to mitigate these toxicities.
DOI: 10.1186/s13014-022-02178-0
ORCID: 0000-0003-1721-0680
Journal: Radiation Oncology (London, England)
Start page: 20
PubMed URL: 36710364
ISSN: 1748-717X
Type: Journal Article
Subjects: Diffusion magnetic resonance imaging
Head and neck cancer
Magnetic resonance imaging
Head and Neck Neoplasms/radiotherapy
Head and Neck Neoplasms/complications
Xerostomia/diagnostic imaging
Diffusion Magnetic Resonance Imaging/methods
Radiation Injuries/etiology
Radiation Injuries/complications
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Mar 30, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.