Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32002
Title: GABAA receptor neurotransmission & epilepsy: principles, disease mechanisms & pharmacotherapy.
Austin Authors: Bryson, Alexander ;Reid, Christopher;Petrou, Steven
Affiliation: The Florey Institute of Neuroscience and Mental Health
The University of Melbourne, Parkville, VIC 3052, Australia
Neurology
Praxis Precision Medicines, Inc., Cambridge, MA 02142, USA
Issue Date: 22-Jan-2023
Date: 2023
Publication information: Journal of Neurochemistry 2023; 165(1)
Abstract: Epilepsy is a common neurological disorder associated with alterations of excitation-inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the most prevalent form of inhibitory neurotransmission and is strongly implicated in both the pathophysiology and treatment of epilepsy, serving as a primary target for antiseizure medications for over a century. It is now established that GABA exerts a multifaceted influence through an array of GABAA receptor subtypes that extends far beyond simply negating excitatory activity. As the role of GABAA neurotransmission within inhibitory circuits is elaborated, this will enable the development of precision therapies that correct the network dysfunction underlying epileptic pathology.
URI: https://ahro.austin.org.au/austinjspui/handle/1/32002
DOI: 10.1111/jnc.15769
ORCID: 0000-0002-0033-8197
Journal: Journal of Neurochemistry
PubMed URL: 36681890
ISSN: 1471-4159
Type: Journal Article
Appears in Collections:Journal articles

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