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Title: Tumor Growth Remains Refractory to Myc Ablation in Host Macrophages.
Austin Authors: Morrow, Riley J;Allam, Amr H;Konecnik, Josh;Baloyan, David;Dijkstra, Christine ;Eissmann, Moritz F ;Jacob, Saumya P;O'Brien, Megan;Poh, Ashleigh R;Ernst, Matthias 
Affiliation: Olivia Newton-John Cancer Research Institute
School of Cancer Medicine, La Trobe University, Heidelberg, VIC 3084, Australia.
Issue Date: 17-Dec-2022
Date: 2022
Publication information: Cells 2022; 11(24)
Abstract: Aberrant expression of the oncoprotein c-Myc (Myc) is frequently observed in solid tumors and is associated with reduced overall survival. In addition to well-recognized cancer cell-intrinsic roles of Myc, studies have also suggested tumor-promoting roles for Myc in cells of the tumor microenvironment, including macrophages and other myeloid cells. Here, we benchmark Myc inactivation in tumor cells against the contribution of its expression in myeloid cells of murine hosts that harbor endogenous or allograft tumors. Surprisingly, we observe that LysMCre-mediated Myc ablation in host macrophages does not attenuate tumor growth regardless of immunogenicity, the cellular origin of the tumor, the site it develops, or the stage along the tumor progression cascade. Likewise, we find no evidence for Myc ablation to revert or antagonize the polarization of alternatively activated immunosuppressive macrophages. Thus, we surmise that systemic targeting of Myc activity may confer therapeutic benefits primarily through limiting Myc activity in tumor cells rather than reinvigorating the anti-tumor activity of macrophages.
DOI: 10.3390/cells11244104
ORCID: 0000-0003-2283-3970
Journal: Cells
PubMed URL: 36552868
ISSN: 2073-4409
Type: Journal Article
Subjects: Myc
gastrointestinal cancer
myeloid cells
Myeloid Cells/metabolism
Appears in Collections:Journal articles

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