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Title: Plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross-sectional and longitudinal study in the AIBL cohort.
Austin Authors: Chatterjee, Pratishtha;Pedrini, Steve;Doecke, James D;Thota, Rohith;Villemagne, Victor L ;Doré, Vincent ;Singh, Abhay K;Wang, Penghao;Rainey-Smith, Stephanie;Fowler, Christopher;Taddei, Kevin;Sohrabi, Hamid R;Molloy, Mark P;Ames, David;Maruff, Paul;Rowe, Christopher C ;Masters, Colin L ;Martins, Ralph N
Affiliation: Macquarie Medical School, Macquarie University, North Ryde, New South Wales, Australia.
School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
Australian eHealth Research Centre, CSIRO, Brisbane, Queensland, Australia.
Department of Psychiatry, University of Pittsburgh, Pennsylvania, Pittsburgh, USA.
Macquarie Business School, Macquarie University, North Ryde, New South Wales, Australia.
College of Science, Health, Engineering and Education, Murdoch University, Perth, Western Australia, Australia.
The Florey Institute of Neuroscience and Mental Health
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia.
National Ageing Research Institute, Parkville, Victoria, Australia.
Molecular Imaging and Therapy
Issue Date: Apr-2023
Date: 2022
Publication information: Alzheimer's & Dementia: the Journal of the Alzheimer's Association 2023; 19(4)
Abstract: Plasma amyloid beta (Aβ)1-42/Aβ1-40 ratio, phosphorylated-tau181 (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) are putative blood biomarkers for Alzheimer's disease (AD). However, head-to-head cross-sectional and longitudinal comparisons of the aforementioned biomarkers across the AD continuum are lacking.
DOI: 10.1002/alz.12724
Journal: Alzheimer's & Dementia
PubMed URL: 36574591
ISSN: 1552-5279
Type: Journal Article
Subjects: Alzheimer's disease
amyloid beta
blood biomarkers
brain amyloid beta
glial fibrillary acidic protein
longitudinal monitoring
neurofilament light
single molecule array
Appears in Collections:Journal articles

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