Investigating Tissue-Specific Abnormalities in Alzheimer's Disease with Multi-Shell Diffusion MRI.

2022-12

Giraldo, Diana L

Smith, Robert E

Struyfs, Hanne

Niemantsverdriet, Ellis

De Roeck, Ellen

Bjerke, Maria

Engelborghs, Sebastiaan

Romero, Eduardo

Sijbers, Jan

Jeurissen, Ben

Alzheimer’s disease

cerebrospinal fluid

cognitive dysfunction

dementia

diffusion MRI

gray matter

whitematter

Journal Article

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10.3233/JAD-220551

Most studies using diffusion-weighted MRI (DW-MRI) in Alzheimer's disease (AD) have focused their analyses on white matter (WM) microstructural changes using the diffusion (kurtosis) tensor model. Although recent works have addressed some limitations of the tensor model, such as the representation of crossing fibers and partial volume effects with cerebrospinal fluid (CSF), the focus remains in modeling and analyzing the WM.

link

Journal of Alzheimer's Disease 2022

Journal of Alzheimer's Disease

1875-8908