Ackermann, Uwe

Jäger, Luise

Rigopoulos, Angela

Burvenich, Ingrid Julienne Georgette

O'Keefe, Graeme Joseph

Scott, Andrew M

2023

Tissue transglutaminase 2 (TG2) is a calcium-dependent enzyme which cross-links proteins. It is overexpressed in many diseases and plays a key role in tissue remodeling, including cell adhesion and migration. Overexpression of TG2 in breast cancer is a marker for patients at risk of recurrence. Non-invasive imaging of TG2 can therefore play an important role in patient management. TG2 probes labeled with the positron emitters 11C and 18F have thus far not found widespread application due to purity and metabolism issues. Our approach was to radiolabel a TG2 selective, 13-mer amino acid peptide, which was modified with a 5-azidopentanoic acid group at the N-terminus via a copper free click chemistry approach.

Nuclear Medicine and Biology 2023; 116-117

1872-9614

Nuclear Medicine and Biology

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https://ahro.austin.org.au/austinjspui/handle/1/31843

Fluorine-18

Hitomi peptide

PET imaging

Transglutaminase 2

18F-labeling and initial in vivo evaluation of a Hitomi peptide for imaging tissue transglutaminase 2.

Journal Article