Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney Transplantation.

2022-12

Collins, Michael G

Fahim, Magid A

Pascoe, Elaine M

Hawley, Carmel M

Johnson, David W

Varghese, Julie

Hickey, Laura E

Clayton, Philip A

Gill, John S

Dansie, Kathryn B

McConnochie, Rachael C

Vergara, Liza A

Kiriwandeniya, Charani

Reidlinger, Donna

Mount, Peter F

Weinberg, Laurence

McArthur, Colin J

Coates, P Toby

Endre, Zoltan H

Goodman, David

Howard, Kirsten

Howell, Martin

Jamboti, Jagadish S

Kanellis, John

Laurence, Jerome M

Lim, Wai H

McTaggart, Steven J

O'Connell, Philip J

Pilmore, Helen L

Wong, Germaine

Chadban, Steven J

Journal Article

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10.1097/TXD.0000000000001399

Delayed graft function (DGF) is a major complication of deceased donor kidney transplantation. Saline (0.9% sodium chloride) is a commonly used intravenous fluid in transplantation but may increase the risk of DGF because of its high chloride content. Better Evidence for Selecting Transplant Fluids (BEST-Fluids), a pragmatic, registry-based, double-blind, randomized trial, sought to determine whether using a balanced low-chloride crystalloid solution (Plasma-Lyte 148) instead of saline would reduce DGF. We sought to evaluate the generalizability of the trial cohort by reporting the baseline characteristics and representativeness of the trial participants in detail.

link

Transplantation Direct 2022

Transplantation Direct