Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/31748
Title: Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.
Austin Authors: Coombes, Brandon J;Millischer, Vincent;Batzler, Anthony;Larrabee, Beth;Hou, Liping;Papiol, Sergi;Heilbronner, Urs;Adli, Mazda;Akiyama, Kazufumi;Akula, Nirmala;Amare, Azmeraw T;Ardau, Raffaella;Arias, Barbara;Aubry, Jean-Michel;Backlund, Lena;Bauer, Michael;Baune, Bernhard T;Bellivier, Frank;Benabarre, Antoni;Bengesser, Susanne;Bhattacharjee, Abesh Kumar;Cervantes, Pablo;Chen, Hsi-Chung;Chillotti, Caterina;Cichon, Sven;Clark, Scott R;Colom, Francesc;Cruceanu, Cristiana;Czerski, Piotr M;Dalkner, Nina;Degenhardt, Franziska;Del Zompo, Maria;DePaulo, J Raymond;Étain, Bruno;Falkai, Peter;Ferensztajn-Rochowiak, Ewa;Forstner, Andreas J;Frisen, Louise;Gard, Sébastien;Garnham, Julie S;Goes, Fernando S;Grigoroiu-Serbanescu, Maria;Grof, Paul;Hashimoto, Ryota;Hauser, Joanna;Herms, Stefan;Hoffmann, Per;Jamain, Stephane;Jiménez, Esther;Kahn, Jean-Pierre;Kassem, Layla;Kato, Tadafumi;Kelsoe, John R;Kittel-Schneider, Sarah;König, Barbara;Kuo, Po-Hsiu;Kusumi, Ichiro;Laje, Gonzalo;Landén, Mikael;Lavebratt, Catharina;Leboyer, Marion;Leckband, Susan G;Maj, Mario;Manchia, Mirko;Martinsson, Lina;McCarthy, Michael J;McElroy, Susan L;Mitchell, Philip B;Mitjans, Marina;Mondimore, Francis M;Monteleone, Palmiero;Nievergelt, Caroline M;Nöthen, Markus M;Novák, Tomas;O'Donovan, Claire;Osby, Urban;Ozaki, Norio;Pfennig, Andrea;Pisanu, Claudia;Potash, James B;Reif, Andreas;Reininghaus, Eva;Rietschel, Marcella;Rouleau, Guy A;Rybakowski, Janusz K;Schalling, Martin;Schofield, Peter R;Schubert, Klaus Oliver;Schweizer, Barbara W;Severino, Giovanni;Shekhtman, Tatyana;Shilling, Paul D;Shimoda, Katzutaka;Simhandl, Christian;Slaney, Claire M;Squassina, Alessio;Stamm, Thomas;Stopkova, Pavla;Tortorella, Alfonso;Turecki, Gustavo;Vieta, Eduard;Witt, Stephanie H;Zandi, Peter P;Fullerton, Janice M;Alda, Martin;Frye, Mark A;Schulze, Thomas G;McMahon, Francis J;Biernacka, Joanna M
Affiliation: Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Munich, Germany.
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Munich, Germany.
Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Barcelona, Spain.
Department of Psychiatry, Mood Disorders Unit, HUG-Geneva University Hospitals, Geneva, Switzerland.
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Department of Psychiatry, University of Münster, Münster, Germany.
INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
The Neuromodulation Unit, McGill University Health Centre, Montreal, Québec, Canada.
Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Mental Health Research Group, IMIM-Hospital del Mar, Barcelona, Spain.
Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Munich, Germany.
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Mood Disorders Center of Ottawa, Ottawa, Ontario, Canada.
Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Munich, Germany.
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Université de Lorraine, Nancy, France.
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
AP-HP, Hôpital Henri Mondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de Précision (FHU ADAPT), Créteil, France.
Office of Mental Health, VA San Diego Healthcare System, San Diego, California, USA.
Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Department of Psychiatry, Lindner Center of Hope/University of Cincinnati, Mason, Ohio, USA.
School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
National Institute of Mental Health, Klecany, Czechia.
Centre for Human Genetics, University of Marburg, Marburg, Germany.
Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Department of Psychiatry & Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Université de Lorraine, Nancy, France.
Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec, Canada.
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Neuroscience Research Australia, Sydney, New South Wales, Australia.
Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.
Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.
Centre for Human Genetics, University of Marburg, Marburg, Germany.
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
National Institute of Mental Health, Klecany, Czechia.
Department of Psychiatry, University of Perugia, Perugia, Italy.
Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Neuroscience Research Australia, Sydney, New South Wales, Australia.
Centre for Human Genetics, University of Marburg, Marburg, Germany.
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
The Florey Institute of Neuroscience and Mental Health
Issue Date: Dec-2021
Date: 2021
Publication information: Complex psychiatry 2021; 7(3-4):80-89
Abstract: Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.
URI: https://ahro.austin.org.au/austinjspui/handle/1/31748
DOI: 10.1159/000519707
ORCID: 
Journal: Complex psychiatry
Start page: 80
End page: 89
PubMed URL: 36408127
Type: Journal Article
Subjects: Adherence
Attention-deficit/hyperactivity disorder
Bipolar disorder
Lithium response
Polygenic risk scores
Appears in Collections:Journal articles

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