Diagnosis, management and follow up of peripheral T-cell lymphomas: a consensus practice statement from the Australasian Lymphoma Alliance.

2022-10

Hapgood, Greg

Latimer, Maya

Lee, Sze Ting

Kuss, Bryone

Lade, Stephen

Tobin, Joshua W D

Purtill, Duncan

Campbell, Belinda A

Prince, H Miles

Hawkes, Eliza A

Shortt, Jake

Radeski, Dejan

AITL

ALCL

PTCL

chemotherapy

peripheral T-cell lymphoma

Journal Article

0000-0002-7980-8496

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0000-0001-8641-456X

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0000-0002-0376-2559

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10.1111/imj.15595

Peripheral T-cell lymphomas (PTCL) represent a heterogeneous disease group accounting for 10% of non-Hodgkin lymphomas. PTCL patients have typically poorer outcomes compared with aggressive B-cell lymphomas. However, such outcomes are heavily dependent on subtype. Although anthracycline-based regimens such as cyclophosphamide, doxorubicin, vincristine and prednisone remain the standard first-line treatment for most aggressive PTCL, there are important variations including incorporation of novel agents, use of radiotherapy and judicious consideration of stem cell transplantation. Relapsed or refractory disease represents a significant area of unmet need where chemotherapy intensification has limited efficacy and novel agents such as brentuximab vedotin and pralatrexate provide additional opportunities for attainment of remission and potential stem cell transplant. In the future, pre-therapy prognostic biomarkers including genomic characterisation, may aid in risk stratification and help guide initial patient management to improve survival. There is an urgent need to understand better the pathogenesis of PTCL to facilitate novel drug combinatorial approaches to improve survival. This position statement represents an evidence-based synthesis of the literature for application in Australian and New Zealand practice.

link

Internal Medicine Journal 2022

Internal Medicine Journal

1445-5994