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Title: Associations Between Obstructive Sleep Apnea (OSA) and COVID-19 Infection and Hospitalization Among U.S. Adults
Austin Authors: Quan, Stuart F.;Weaver, Matthew;Czeisler, Mark;Barger, Laura;Booker, Lauren;Howard, Mark;Jackson, Melinda;Lane, Rashon;McDonald, Christine F ;Ridgers, Anna;Robbins, Rebecca;Varma, Prerna;Rajaratnam, Shantha;Czeisler, Charles
Affiliation: Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA;
Francis Weld Peabody Society, Harvard Medical School, Boston, MA
School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia
Institute for Breathing and Sleep
University Department of Rural Health, La Trobe Rural Health School, La Trobe University, Bendigo, Victoria, Australia
Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia;
Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
Respiratory and Sleep Medicine
Division of Sleep Medicine, Harvard Medical School, Boston, MA
Faculty of Medicine, Monash University, Melbourne Australia
Issue Date: 26-Sep-2022
Publication information: Preprints 2022, 2022090383
Abstract: Background: Medical comorbidities increase the risk of severe COVID-19 infection. In some studies, obstructive sleep apnea (OSA) has been identified as a comorbid condition that is associated with an increased prevalence of COVID-19 infection and hospitalization, but few have investigated this association in a general population. Research Question: In a general population, is OSA associated with increased odds of COVID-19 infection and hospitalization and are these altered with COVID-19 vaccination? Study Design: Cross-sectional survey of a diverse sample of 15,057 U.S. adults Results: COVID-19 infection and hospitalization rates were 38.9% and 2.9% respectively. OSA or OSA symptoms were reported in 19.4%. In logistic regression models adjusted for demographic, socio-economic and comorbid medical conditions, OSA was positively associated with COVID-19 infection (aOR: 1.58, 95%CI: 1.39-1.79) and COVID-19 hospitalization (aOR: 1.55, 95% CI: 1.17-2.05). In fully adjusted models, boosted vaccination status was protective against both infection and hospitalization. Boosted vaccination status attenuated the association between OSA and COVID-19 related hospitalization, but not infection. Participants with untreated or symptomatic OSA were at greater risk for COVID-19 infection; those with untreated, but not symptomatic OSA were more likely to be hospitalized. Interpretation: In a general population sample, OSA is associated with a greater likelihood of having had a COVID-19 infection and a COVID-19 hospitalization with the greatest impact observed among persons experiencing OSA symptoms or who were untreated for their OSA. Boosted vaccination status attenuated the association between OSA and COVID-19 related hospitalization.
DOI: 10.20944/preprints202209.0383.v1
Journal: Preprints
Type: Journal Article
General Medical Research
Appears in Collections:Journal articles

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