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Title: | Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study. | Austin Authors: | Ng, Sweet Ping ;Cardenas, Carlos E;Bahig, Houda;Elgohari, Baher;Wang, Jihong;Johnson, Jason M;Moreno, Amy C;Shah, Shalin J;Garden, Adam S;Phan, Jack;Gunn, G Brandon;Frank, Steven J;Ding, Yao;Na, Lumine;Yuan, Ying;Urbauer, Diana;Mohamed, Abdallah S R;Rosenthal, David I;Morrison, William H;MacManus, Michael P;Fuller, Clifton D | Affiliation: | Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA Department of Clinical Oncology and Nuclear Medicine, Mansoura University, Mansoura 35516, Egypt.. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA Olivia Newton-John Cancer Wellness and Research Centre Department of Biostatistics, Peter MacCallum Cancer Centre, Melbourne, VIC 3000,Australia Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000,Australia Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.. Radiation Oncology |
Issue Date: | 31-Aug-2022 | Date: | 2022 | Publication information: | Current Oncology 2022; 29(9): 6303-6313 | Abstract: | Background: The PREDICT-HN study aimed to systematically assess the kinetics of imaging MR biomarkers during head and neck radiotherapy. Methods: Patients with intact squamous cell carcinoma of the head and neck were enrolled. Pre-, during, and post-treatment MRI were obtained. Serial GTV and ADC measurements were recorded. The correlation between each feature and the GTV was calculated using Spearman's correlation coefficient. The linear mixed model was used to evaluate the change in GTV over time. Results: A total of 41 patients completed the study. The majority (76%) had oropharyngeal cancer. A total of 36 patients had intact primary tumours that can be assessed on MRI, and 31 patients had nodal disease with 46 nodes assessed. Median primary GTV (GTVp) size was 14.1cc. The rate of GTVp shrinkage was highest between pre-treatment and week 4. Patients with T3-T4 tumours had a 3.8-fold decrease in GTVp compared to T1-T2 tumours. The ADC values correlated with residual GTVp. The median nodal volume (GTVn) was 12.4cc. No clinical features were found to correlate with GTVn reduction. The overall change in ADC for GTVn from pre-treatment was significant for 35th-95th percentiles in weeks 1-4 (p < 0.001). Conclusion: A discrepancy in the trajectory of ADC between primary and nodal sites suggested that they exhibit different treatment responses and should be analysed separately in future studies. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30942 | DOI: | 10.3390/curroncol29090495 | ORCID: | 0000-0003-1414-3849 0000-0001-6762-6807 0000-0001-5977-6004 0000-0003-2064-7613 0000-0002-0900-5815 0000-0002-5264-3994 |
Journal: | Current Oncology (Toronto, Ont.) | PubMed URL: | 36135064 | Type: | Journal Article | Subjects: | apparent diffusion coefficient gross tumour volume head and neck radiotherapy |
Appears in Collections: | Journal articles |
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