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Title: The neurobiology of Pavlovian safety learning: Towards an acquisition-expression framework.
Austin Authors: Laing, Patrick A F;Felmingham, Kim L;Davey, Christopher G;Harrison, Ben J
Affiliation: Psychiatry (University of Melbourne)
Melbourne School of Psychological Sciences, The University of Melbourne,Australia
Issue Date: 21-Sep-2022
Date: 2022
Publication information: Neuroscience and Biobehavioral Reviews 2022; 142: 104882
Abstract: Safety learning creates associations between conditional stimuli and the absence of threat. Studies of human fear conditioning have accumulated evidence for the neural signatures of safety over various paradigms, aligning on several common brain systems. While these systems are often interpreted as underlying safety learning in a generic sense, they may instead reflect the expression of learned safety, pertaining to processes of fear inhibition, positive affect, and memory. Animal models strongly suggest these can be separable from neural circuits implicated in the conditioning process itself (or safety acquisition). While acquisition-expression distinctions are ubiquitous in behavioural science, this lens has not been applied to safety learning, which remains a novel area in the field. In this mini-review, we overview findings from prevalent safety paradigms in humans, and synthesise these with insights from animal models to propose that the neurobiology of safety learning be conceptualised along an acquisition-expression model, with the aim of stimulating richer brain-based characterisations of this important process.
DOI: 10.1016/j.neubiorev.2022.104882
Journal: Neuroscience and Biobehavioral Reviews
PubMed URL: 36150453
Type: Journal Article
Subjects: Basal ganglia
Fear conditioning
Safety learning
Appears in Collections:Journal articles

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