Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30783
Title: Antibody-drug conjugates: beyond current approvals and potential future strategies.
Austin Authors: Menon, Siddharth;Parakh, Sagun ;Scott, Andrew M ;Gan, Hui K 
Affiliation: College of Science, Health and Engineering, La Trobe University, Melbourne Victoria 3086, Australia
Olivia Newton-John Cancer Wellness and Research Centre
Issue Date: 2022
Date: 2022
Publication information: Exploration of Targeted Anti-tumor Therapy 2022; 3(2): 252-277
Abstract: The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in recent years have fuelled the ongoing development of this class of drugs. These novel agents combine the benefits of high specific targeting of oncogenic cell surface antigens with the additional cell kill from high potency cytotoxic payloads, thus achieving wider therapeutic windows. This review will summarise the clinical activity of ADCs in tumour types not covered elsewhere in this issue, such as gastrointestinal (GI) and genitourinary (GU) cancers and glioblastoma (GBM). In addition to the ongoing clinical testing of existing ADCs, there is substantial preclinical and early phase testing of newer ADCs or ADC incorporating strategies. This review will provide selected insights into such future development, focusing on the development of novel ADCs against new antigen targets in the tumour microenvironment (TME) and combination of ADCs with immuno-oncology (IO) agents.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30783
DOI: 10.37349/etat.2022.00082
ORCID: https://orcid.org/0000-0003-3863-6445
https://orcid.org/0000-0003-3891-2489
https://orcid.org/0000-0002-6656-295X
https://orcid.org/0000-0001-7319-8546
Journal: Exploration of Targeted Anti-tumor Therapy
PubMed URL: 36046842
Type: Journal Article
Subjects: Antibody-drug conjugates
immunotherapy
tumour microenvironment
Appears in Collections:Journal articles

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