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dc.contributor.authorVajda, Frank J E-
dc.contributor.authorO'Brien, Terence J-
dc.contributor.authorGraham, Janet-
dc.contributor.authorHitchcock, Alison A-
dc.contributor.authorPerucca, Piero-
dc.contributor.authorLander, Cecilie M-
dc.contributor.authorEadie, Mervyn J-
dc.identifier.citationActa Neurologica Scandinavica 2022; 146(5): 610-614en
dc.description.abstractTo investigate control of epileptic seizures during pairs of successive pregnancies in antiseizure medication (ASM)-treated women with epilepsy. Analysis of seizure freedom rates during 436 pairs of successive pregnancies in Australian women with epilepsy, in nearly all instances long-standing epilepsy. There was a higher rate of seizure-free second pregnancies compared with first paired pregnancies (63.1% vs. 51.4%; Relative Risk (R.R.) = 1.2277; 95% CI 1.0930, 1.3789) and of seizure-free pre-pregnancy years before second as compared with first paired pregnancies in the same women (63.6% vs. 52.4%; R.R. = 1.2616; 95% CI 1.1337, 1.4040). In 108 women whose ASM therapy was unaltered throughout both of their pregnancies, the seizure-freedom rate was higher in the second of the paired pregnancies (82.4% vs. 69.4%; R.R. = 1.1867, 95% CI 1.0189, 1.3821). Altered ASM therapy after the first of a pair of successive pregnancies did not fully account for the better overall seizure control in the corresponding second pregnancies. Some additional factor may have been in operation, possibly a greater preparedness to undertake a further pregnancy if seizures were already fully controlled.en
dc.subjectantiseizure medicationen
dc.subjectseizure freedomen
dc.subjectsuccessive pregnanciesen
dc.titleSeizure control in successive pregnancies in Australian women with epilepsy.en
dc.typeJournal Articleen_US
dc.identifier.journaltitleActa Neurologica Scandinavicaen
dc.identifier.affiliationComprehensive Epilepsy Programen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationRoyal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland, Australiaen
dc.identifier.affiliationDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.pubmedid35986483-, Piero
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone- Epilepsy Program-
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