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Title: Seizure control in successive pregnancies in Australian women with epilepsy.
Austin Authors: Vajda, Frank J E;O'Brien, Terence J;Graham, Janet;Hitchcock, Alison A;Perucca, Piero ;Lander, Cecilie M;Eadie, Mervyn J
Affiliation: Comprehensive Epilepsy Program
Medicine (University of Melbourne)
Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland, Australia
Department of Neurology, Alfred Health, Melbourne, Victoria, Australia
Department of Neuroscience, Monash University, Melbourne, Victoria, Australia
Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Issue Date: 19-Aug-2022
Date: 2022
Publication information: Acta Neurologica Scandinavica 2022; 146(5): 610-614
Abstract: To investigate control of epileptic seizures during pairs of successive pregnancies in antiseizure medication (ASM)-treated women with epilepsy. Analysis of seizure freedom rates during 436 pairs of successive pregnancies in Australian women with epilepsy, in nearly all instances long-standing epilepsy. There was a higher rate of seizure-free second pregnancies compared with first paired pregnancies (63.1% vs. 51.4%; Relative Risk (R.R.) = 1.2277; 95% CI 1.0930, 1.3789) and of seizure-free pre-pregnancy years before second as compared with first paired pregnancies in the same women (63.6% vs. 52.4%; R.R. = 1.2616; 95% CI 1.1337, 1.4040). In 108 women whose ASM therapy was unaltered throughout both of their pregnancies, the seizure-freedom rate was higher in the second of the paired pregnancies (82.4% vs. 69.4%; R.R. = 1.1867, 95% CI 1.0189, 1.3821). Altered ASM therapy after the first of a pair of successive pregnancies did not fully account for the better overall seizure control in the corresponding second pregnancies. Some additional factor may have been in operation, possibly a greater preparedness to undertake a further pregnancy if seizures were already fully controlled.
DOI: 10.1111/ane.13688
ORCID: 0000-0001-5570-7538
Journal: Acta Neurologica Scandinavica
PubMed URL: 35986483
PubMed URL:
Type: Journal Article
Subjects: antiseizure medication
seizure freedom
successive pregnancies
Appears in Collections:Journal articles

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