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Title: Cribriform pattern disease over-represented in pelvic lymph node metastases identified on 68GA PSMA-PET/CT.
Austin Authors: Bolton, Damien M ;Hong, Anne;Papa, Nathan;Perera, Marlon ;Kelly, Brian D ;Duncan, Catriona;Clouston, David;Lawrentschuk, Nathan
Affiliation: Surgery (University of Melbourne)
Department of Preventive Medicine Monash University Melbourne Australia
Urology Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA
Department of Urology Peter MacCallum Cancer Centre Melbourne Australia
Tissupath Melbourne Australia
Issue Date: 21-Apr-2022
Date: 2022-09
Publication information: BJUI Compass 2022; 3(5): 371-376
Abstract: To determine whether any specific histologic subtype of prostate cancer was preferentially represented in pelvic lymph node metastases identified on 68GA-PSMA-PET/CT. A consecutive series of 66 men with biochemical recurrent prostate cancer was evaluated with 68GA-PSMA-PET/CT. Where disease was confined to pelvic lymph nodes, patients were offered salvage extended pelvic lymph node dissection. Twenty patients ultimately proceeded to extended bilateral template pelvic lymph node dissection. Lymph node positivity and the histologic subtype of apparent cancer were assessed, as was PSA response to this intervention. Mean PSA at time of PSMA scanning for patients undergoing lymphadenectomy was 2.49 (n = 20, range 0.21-12.0). In 16 of 20 patients, there was evidence of metastatic cribriform pattern prostate cancer in excised nodes (100% cribriform pattern in 11/16). Only four of 20 patients had no evidence of this histologic subtype of disease. PSA response was not related to the presence or proportional amount of cribriform pattern disease identified. Cribriform pattern adenocarcinoma appears to be the histologic subtype preferentially identified in pelvic lymph nodes on 68GA-PSMA-PET/CT. The use of PSMA-PET may be particularly valuable in staging of primary or biochemically recurrent prostate cancer in patients with cribriform pattern disease detected on initial biopsy or radical prostatectomy. Further research is required to further confirm the observed association.
DOI: 10.1002/bco2.151
ORCID: 0000-0001-7786-0605
Journal: BJUI Compass
PubMed URL: 35950036
PubMed URL:
Type: Journal Article
Subjects: PSMA‐PET
cribriform pattern
pelvic lymph nodes
prostate cancer
Appears in Collections:Journal articles

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