Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30708
Title: A companion to the preclinical common data elements for rodent genetic epilepsy models. A Report of the TASK3-WG1B: Pediatric and Genetic models Working Group of the ILAE/AES Joint Translational Task Force.
Austin Authors: Mantegazza, Massimo;Auvin, Stėphane;Barker-Haliski, Melissa;Katsarou, Anna-Maria;Kubova, Hana;Galanopoulou, Aristea S;Semple, Bridgette;Reid, Christopher A
Affiliation: Department of Neurology, Alfred Health, Prahran, VIC, Australia..
Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia..
Université Côte d'Azur, CNRS UMR7275, Inserm, LabEx ICST, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France..
Epilepsy Research Centre
The Florey Institute of Neuroscience and Mental Health
Department of Neuroscience, Monash University, Prahran, VIC, Australia..
Université de Paris, INSERM UMR 1141, Service de Neurologie Pédiatrique, Hôpital Robert-Debré, APHP, Paris, France..
Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, USA..
Saul R. Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, Bronx, New York, U.S.A..
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic..
Institut Universitaire de France (IUF), Paris, France..
Issue Date: 11-Aug-2022
Date: 2022
Publication information: Epilepsia Open 2022; online first: 11 August
Abstract: Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost-effectiveness and scientific rigor of the studies performed. Here we present two case report forms (CRFs) describing common data elements (CDE) for genetic rodent models, developed by the TASK3-WG1B Working Group of the International League Against Epilepsy (ILAE) / American Epilepsy Society (AES) Joint Translational Task Force. The first CRF relates to genetic rodent models that have been engineered based on variants described in epilepsy patients. The second CRF encompasses both spontaneous and inbred rodent models. This companion piece describes the elements and discusses the important factors to consider before documenting each required element. These CRFs provide tools that allow investigators to more uniformly describe core experimental data on different genetic models across laboratories, with the aim of improving experimental reproducibility and thus translational impact of such studies.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30708
DOI: 10.1002/epi4.12642
ORCID: 0000-0003-3874-9749
0000-0002-8175-0553
0000-0003-0133-4582
0000-0002-2016-7428
0000-0002-0472-2903
0000-0002-2535-0491
0000-0002-1457-8028
Journal: Epilepsia Open
PubMed URL: 35951766
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35951766/
Type: Journal Article
Subjects: Rodent models
common data element
genetic
reproducibility
Appears in Collections:Journal articles

Show full item record

Page view(s)

12
checked on Oct 11, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.