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Title: The Effects of Targeted Changes in Systemic Blood Flow and Mean Arterial Pressure on Urine Oximetry During Cardiopulmonary Bypass.
Austin Authors: Hu, Raymond T C ;Yanase, Fumitaka ;McCall, Peter R ;Evans, Roger;Raman, Jaishankar;Bellomo, Rinaldo 
Affiliation: Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia..
The Florey Institute of Neuroscience and Mental Health
Department of Cardiac Surgery, St. Vincent's Hospital, Melbourne, Victoria, Australia..
Department of Critical Care, Melbourne Medical School, The University of Melbourne, Victoria, Australia..
Intensive Care
Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia..
Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Victoria, Australia..
Cardiac Surgery
Issue Date: Sep-2022
Date: 2022
Publication information: Journal of cardiothoracic and vascular anesthesia 2022; 36(9): 3551-3560
Abstract: Poor medullary oxygenation is implicated in the evolution of acute kidney injury. The authors sought to determine if increasing systemic flow and mean arterial pressure could improve urine oxygen tension (PuO2) measured in the bladder, a surrogate of kidney medullary oxygenation, in patients undergoing on-pump cardiac surgery. Randomized crossover study. University-affiliated hospital. Twenty adult patients undergoing cardiopulmonary bypass (CPB) with expected cross-clamp time of >60 minutes and estimated glomerular filtration rate of >30 mL/min/1.73m2. Sequential 20-minute periods of 2 interventions: Intervention H ("High") or Intervention N ("Normal"). The order of interventions was determined by randomization. Intervention H: targeted CPB flow 3.0 L/min/m2 and mean arterial pressure (MAP) 80 mmHg. Intervention N: targeted CPB flow 2.4 L/min/m2 and MAP 65 mmHg. PuO2 was measured by an oxygen sensor introduced into the bladder via a urinary catheter. Clear separation was achieved in CPB flow and MAP between intervention periods (p < 0.001 for group-time interaction). PuO2 during Intervention H was higher than during Intervention N (p < 0.001 for group-time interaction). After 17 minutes, PuO2 was statistically higher in Intervention H at each time point. There were no differences in markers of hemolysis between interventions. PuO2 was higher when systemic flow and MAP were increased during CPB. These findings suggest that PuO2 is responsive to changes in hemodynamics and that higher flow and pressure may improve medullary oxygenation.
DOI: 10.1053/j.jvca.2022.05.023
ORCID: 0000-0002-0169-0600
Journal: Journal of cardiothoracic and vascular anesthesia
PubMed URL: 35718621
PubMed URL:
Type: Journal Article
Subjects: acute kidney injury
cardiopulmonary bypass
renal physiology
urine oximetry
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