Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30687
Title: CD137L and CD4 T cells limit BCL6-expressing pre-germinal center B cell expansion and BCL6-driven B cell malignancy.
Austin Authors: Ding, Zhoujie;Quast, Isaak;Yan, Feng;Liao, Yang;Pitt, Catherine;O-Donnell, Kristy;Robinson, Marcus J;Shi, Wei;Kallies, Axel;Zotos, Dimitra;Tarlinton, David M
Affiliation: The Peter Doherty Institute, University of Melbourne, Melbourne, VIC, Australia..
Department of Immunology & Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia..
Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia..
Olivia Newton-John Cancer Research Institute
Issue Date: 2-Aug-2022
Date: 2022
Publication information: Immunology and Cell Biology 2022-10; 100(9): 705-717
Abstract: Aberrant expression of the proto-oncogene BCL6 is a driver of tumorigenesis in diffuse large B cell lymphoma (DLBCL). Mice overexpressing BCL6 from the B cell-specific immunoglobulin heavy chain μ intron promoter (Iμ-Bcl6Tg/+ ) develop B cell lymphomas with features typical of human DLBCL. While B cell lymphoma development in these mice is tightly controlled by T cells, the mechanisms of this immune surveillance are poorly understood. Here we show that CD4 T cells contribute to the control of lymphoproliferative disease in lymphoma-prone Iμ-Bcl6Tg/+ mice. We reveal that this CD4 T-cell immuno-surveillance requires signaling by the co-stimulatory molecule CD137 ligand (CD137L; also known as 4-1BBL), which may promote the transition of pre-malignant B cells with an activated phenotype into the germinal center stage via reverse signalling, preventing their hazardous accumulation. Thus, CD137L-mediated CD4 T cell immuno-surveillance adds another layer of protection against B-cell malignancy to that provided by CD8 T-cell cytotoxicity.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30687
DOI: 10.1111/imcb.12578
ORCID: 0000-0001-6517-8537
0000-0001-5677-3078
0000-0001-9928-686X
Journal: Immunology and Cell Biology
PubMed URL: 35916066
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35916066/
Type: Journal Article
Subjects: B cell malignancy
BCL6
CD137L
CD4 T cells
tumour immunity
Appears in Collections:Journal articles

Show full item record

Page view(s)

14
checked on Apr 19, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.