Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30611
Title: Methylomic and transcriptomic characterization of postoperative systemic inflammatory dysregulation.
Austin Authors: Bain, Chris R;Myles, Paul S;Taylor, Rachael;Trahair, Hugh;Lee, Yin Peng;Croft, Larry;Peyton, Philip J ;Painter, Thomas;Chan, Matthew T V;Wallace, Sophie;Corcoran, Tomás;Shaw, Andrew D;Paul, Eldho;Ziemann, Mark;Bozaoglu, Kiymet
Affiliation: Genomics and Systems Biology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia..
Department of Anesthesiology and Perioperative Medicine, Alfred Hospital, Melbourne Victoria, Australia..
Department of Anesthesiology and Perioperative Medicine, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia..
Department of Anesthesiology and Perioperative Medicine, Alfred Hospital, Melbourne Victoria, Australia..
Genomics Centre, School of life and environmental sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Waurn Ponds, Victoria, Australia..
Anaesthesia
Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia..
Department of Anesthesia, Royal Adelaide Hospital, Discipline of Acute Care Medicine, University of Adelaide, Adelaide, South Australia, Australia..
Department of Anesthesia and Intensive Care, The Chinese Universtiy of Hong Kong, Hong Kong Special Administrative Region, China..
Department of Anesthesia and Pain Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia..
School of Public Health and Preventative Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia..
Department of Anesthesiology and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina..
Department of Intensive Care and Resuscitation, Cleveland Clinic, Cleveland, Ohio..
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia..
Genomics Centre, School of life and environmental sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Waurn Ponds, Victoria, Australia..
Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia..
Murdoch Children's Research Institute and Department of Pediatrics, University of Melbourne, Victoria, Australia..
Issue Date: Sep-2022
metadata.dc.date: 2022
Publication information: Translational Research : the Journal of Laboratory and Clinical Medicine 2022; 247: 79-98
Abstract: In this study, we define and validate a state of postoperative systemic inflammatory dysregulation (PSID) based on postoperative phenotypic extremes of plasma C-reactive protein concentration following major abdominal surgery. PSID manifested clinically with significantly higher rates of sepsis, complications, longer hospital stays and poorer short, and long-term outcomes. We hypothesized that PSID will be associated with, and potentially predicted by, altered patterns of genome-wide peripheral blood mononuclear cell differential DNA methylation and gene expression. We identified altered DNA methylation and differential gene expression in specific immune and metabolic pathways during PSID. Our findings suggest that dysregulation results in, or from, dramatic changes in differential DNA methylation and highlights potential targets for early detection and treatment. The combination of altered DNA methylation and gene expression suggests that dysregulation is mediated at multiple levels within specific gene sets and hence, nonspecific anti-inflammatory treatments such as corticosteroids alone are unlikely to represent an effective therapeutic strategy.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30611
DOI: 10.1016/j.trsl.2022.04.004
ORCID: 0000-0003-1185-2869
PubMed URL: 35470009
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35470009/
Type: Journal Article
Appears in Collections:Journal articles

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