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Title: Influence of moderate-hypothermia on renal and cerebral haemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep.
Austin Authors: Jufar, Alemayehu H;May, Clive N;Evans, Roger G;Cochrane, Andrew D;Marino, Bruno;Hood, Sally G;McCall, Peter R ;Bellomo, Rinaldo ;Lankadeva, Yugeesh R
Affiliation: The Florey Institute of Neuroscience and Mental Health
Department of Critical Care, Melbourne Medical School, University of Melbourne, Victoria, Australia..
Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Victoria, Australia..
Department of Cardiothoracic Surgery, Monash Health and Department of Surgery (School of Clinical Sciences at Monash Health), Monash University, Melbourne, Victoria, Australia..
Cellsaving and Perfusion Resources, Melbourne, Victoria, Australia..
Issue Date: 21-Jul-2022
Date: 2022
Publication information: Acta Physiologica (Oxford, England) 2022; 236(1): e13860
Abstract: Cardiac surgery requiring cardiopulmonary bypass (CPB) can result in renal and cerebral injury. Intra-operative tissue hypoxia could contribute to such organ injury. Hypothermia, however, may alleviate organ hypoxia. Therefore, we tested whether moderate-hypothermia (30o C) improves cerebral and renal tissue perfusion and oxygenation during ovine CPB. Ten sheep were studied while conscious, under stable anaesthesia and during 3 hours of CPB. In a randomised within-animal cross-over design, 5 sheep commenced CPB at a target body temperature of 30 o C (moderate-hypothermia). After 90 minutes, body temperature was increased to 36 o C (standard-procedure). The remaining 5 sheep were randomised to the opposite order of target body temperature. Compared with the standard-procedure, moderately-hypothermic CPB reduced renal oxygen delivery (-34.8 ± 19.6%, P = 0.003) and renal oxygen consumption (-42.7 ± 35.2%, P = 0.04). Nevertheless, moderately-hypothermic CPB did not significantly alter either renal cortical or medullary tissue PO2 . Moderately-hypothermic CPB also did not significantly alter cerebral perfusion, cerebral tissue PO2 , or cerebral oxygen saturation compared with the standard-procedure. Compared with anaesthetised state, standard-procedure reduced renal medullary PO2 (-21.0 ± 13.8 mmHg, P = 0.014) and cerebral oxygen saturation (65.0 ± 7.0 to 55.4 ± 9.6%, P = 0.022) but did not significantly alter either renal cortical or cerebral PO2 . Ovine experimental CPB leads to renal medullary tissue hypoxia. Moderately-hypothermic CPB did not improve cerebral or renal tissue oxygenation. In the kidney, this is probably because renal tissue oxygen consumption is matched by reduced renal oxygen delivery.
DOI: 10.1111/apha.13860
Journal: Acta physiologica (Oxford, England)
PubMed URL: 35862484
PubMed URL:
Type: Journal Article
Subjects: Cardiac surgery
cerebral oxygenation
cerebral perfusion
renal oxygenation
renal perfusion
Appears in Collections:Journal articles

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