Intrasaccular flow disruption for ruptured aneurysms: an international multicenter study.

2023-09

Diestro, Jose Danilo Bengzon

Dibas, Mahmoud

Adeeb, Nimer

Regenhardt, Robert W

Vranic, Justin E

Guenego, Adrien

Lay, Sovann V

Renieri, Leonardo

Al Balushi, Ali

Shotar, Eimad

Premat, Kevin

El Naamani, Kareem

Saliou, Guillaume

Möhlenbruch, Markus A

Lylyk, Ivan

Foreman, Paul M

Vachhani, Jay A

Župančić, Vedran

Hafeez, Muhammad U

Rutledge, Caleb

Rai, Hamid

Tutino, Vincent M

Mirshani, Shervin

Ghozy, Sherief

Harker, Pablo

Alotaibi, Naif M

Rabinov, James D

Ren, Yifan

Schirmer, Clemens M

Goren, Oded

Piano, Mariangela

Kuhn, Anna Luisa

Michelozzi, Caterina

Elens, Stephanie

Starke, Robert M

Hassan, Ameer

Salehani, Arsalaan

Nguyen, Anh

Jones, Jesse

Psychogios, Marios

Spears, Julian

Parra-Fariñas, Carmen

Bres Bullrich, Maria

Mayich, Michael

Salem, Mohamed M

Burkhardt, Jan-Karl

Jankowitz, Brian T

Domingo, Ricardo A

Huynh, Thien

Tawk, Rabih

Ulfert, Christian

Lubicz, Boris

Panni, Pietro

Puri, Ajit S

Pero, Guglielmo

Griessenauer, Christoph J

Asadi, Hamed

Siddiqui, Adnan

Ducruet, Andrew F

Albuquerque, Felipe C

Du, Rose

Kan, Peter

Kalousek, Vladimir

Lylyk, Pedro

Boddu, Srikanth Reddy

Stapleton, Christopher J

Knopman, Jared

Jabbour, Pascal

Tjoumakaris, Stavropoula

Clarençon, Frédéric

Limbucci, Nicola

Aziz-Sultan, Mohammad A

Cuellar-Saenz, Hugo H

Cognard, Christophe

Patel, Aman B

Dmytriw, Adam A

Aneurysm

Journal Article

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10.1136/jnis-2022-019153

The Woven EndoBridge (WEB) device is a novel intrasaccular flow disruptor tailored for bifurcation aneurysms. We aim to describe the degree of aneurysm occlusion at the latest follow-up, and the rate of complications of aneurysms treated with the WEB device stratified according to rupture status. Our data were taken from the WorldWideWeb Consortium, an international multicenter cohort including patients treated with the WEB device. Aneurysms were classified into two groups: ruptured and unruptured. We compared clinical and radiologic outcomes of both groups. Propensity score matching (PSM) was done to match according to age, gender, bifurcation, location, prior treatment, neck, height, dome width, daughter sac, incorporated branch, pretreatment antiplatelets, and last imaging follow-up. The study included 676 patients with 691 intracranial aneurysms (529 unruptured and 162 ruptured) treated with the WEB device. The PSM analysis had 55 pairs. In both the unmatched (85.8% vs 84.3%, p=0.692) and matched (94.4% vs 83.3%, p=0.066) cohorts there was no significant difference in the adequate occlusion rate at the last follow-up. Likewise, there were no significant differences in both ischemic and hemorrhagic complications between the two groups. There was no documented aneurysm rebleeding after WEB device implantation. There was no significant difference in both the radiologic outcomes and complications between unruptured and ruptured aneurysms. Our findings support the feasibility of treatment of ruptured aneurysms with the WEB device.

link

Journal of Neurointerventional Surgery 2023-09; 15(9)

Journal of neurointerventional surgery