Role of renin-angiotensin system antagonists on long-term mortality post-percutaneous coronary intervention in reduced and preserved ejection fraction.

2022-07

Prosser, Hamish C

Peck, Kah Yong

Dinh, Diem

Roberts, Louise

Chandrasekhar, Jaya

Brennan, Angela

Duffy, Stephen J

Clark, David J

Ajani, Andrew E

Oqueli, Ernesto

Sebastian, Martin

Reid, Christopher M

Freeman, Melanie

Sajeev, Jithin K

Teh, Andrew W

Angiotensin converting enzyme inhibitors

Angiotensin receptor blockers

Heart failure

Percutaneous coronary intervention

STEMI/NSTEMI

Journal Article

0000-0003-4074-3610

10.1007/s00392-021-01985-x

The use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II-receptor blockers (ARBs) post-myocardial infarction (MI) is supported by evidence based on trials performed in the thrombolysis era. This was prior to primary percutaneous coronary intervention (PCI) being routine practice, and with little direct evidence for the use of these medications in patients with preserved left ventricular (LV) function. This study sought to determine whether there is an association between ACEi/ARB use after PCI for acute coronary syndrome (ACS) and long-term all-cause mortality, with a particular focus on patients with preserved LV function. This multicentre, observational study evaluated prospectively collected data of 21,388 patients (> 18 years old) that underwent PCI for NSTEMI and STEMI between 2005 and 2018, and were alive at 30 day follow-up. In total, 83.8% of patients were using ACEi/ARBs. Kaplan-Meier analysis demonstrated ACEi/ARB use was associated with a significantly lower mortality in the entire cohort (15.0 vs. 22.7%; p < 0.001) with a mean follow-up of 5.58 years; and independently associated with 24% lower mortality by Cox proportional hazards modelling (HR 0.76, CI 0.67-0.85, p < 0.001). ACEi/ARB therapy was also associated with significantly lower mortality in patients with reduced or preserved LV function, with greater survival benefit with worse LV dysfunction. ACEi/ARB therapy post-PCI is associated with significantly lower long-term mortality in patients with reduced and preserved LV function. These findings provide contemporary evidence for using these agents in the current era of routine primary PCI, including those with preserved EF.

link

Clinical Research in Cardiology 2022; 111(7):776-786.

Clinical research in cardiology : official journal of the German Cardiac Society