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Title: Neurological factors and Cesarean section in Australian women with epilepsy.
Austin Authors: Vajda, F J E;O'Brien, T J;Graham, J E;Hitchcock, A A;Perucca, Piero ;Kuhn, R;Lander, C M;Eadie, M J
Affiliation: Comprehensive Epilepsy Program
Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia..
Medicine (University of Melbourne)
Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia..
Victorian Assisted Reproductive Treatment Authority, Melbourne, VIC, Australia..
Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia..
Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia..
Issue Date: Jul-2022
Date: 2022
Publication information: Epilepsy & behavior : E&B 2022; 132: 108740
Abstract: To analyze the records of the pregnancies of 2283 Australian women with epilepsy in the Australian Register of Antiepileptic Drugs in Pregnancy database to identify neurological factors relevant to the Cesarean sections carried out in these pregnancies. The Cesarean section rate in Australian women overall increased by an average of 0.59% annually over 20 years, from 26.0% to its calculated 2020 value of 37.3%. For the operations in women with epilepsy, the corresponding figures were 0.71% annually, and 34.4% and 48.7%. The average annual rate of increase for pre-labor operations was 0.89% to a 2020 value of 39.1%, the annual rate for operations during labor showing no statistically significant change. Multivariate regression analysis identified a number of characteristics of women with epilepsy that were statistically significantly associated with an increased likelihood of Cesarean section, but of these only seizures continuing to occur in the third trimester and having chronic illness, in particular migraine, were neurological ones. In 70 migraine-affected women, the Cesarean section rate was 51.4%, compared with 39% in the remaining pregnancies (P < 0.05). Having seizures in the final trimester of pregnancy and having chronic neurological illness, especially migraine, favored Cesarean section being carried out in Australian women with epilepsy, but did not adequately account for the increasing rates of occurrence of the operation over the past 20 years.
DOI: 10.1016/j.yebeh.2022.108740
ORCID: 0000-0002-7855-7066
Journal: Epilepsy & behavior : E&B
PubMed URL: 35636349
Type: Journal Article
Subjects: Cesarean section
Appears in Collections:Journal articles

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