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Title: Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges.
Austin Authors: Nuyts, Sandra;Bollen, Heleen;Ng, Sweet Ping ;Corry, June;Eisbruch, Avraham;Mendenhall, William M;Smee, Robert;Strojan, Primoz;Ng, Wai Tong;Ferlito, Alfio
Affiliation: Department of Radiation Oncology, The Prince of Wales Cancer Centre, Sydney, NSW 2031, Australia..
Laboratory of Experimental Radiotherapy, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium..
Radiation Oncology
Division of Medicine, Department of Radiation Oncology, St. Vincent's Hospital, The University of Melbourne, Melbourne, VIC 3000, Australia..
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA..
Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL 32209, USA..
Department of Radiation Oncology, Institute of Oncology, University of Ljubljana, 1000 Ljubljana, Slovenia..
Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China..
Coordinator of the International Head and Neck Scientific Group, 35125 Padua, Italy..
Department of Oncology, Leuven Cancer Institute, Universitair Ziekenhuis Leuven, 3000 Leuven, Belgium..
Issue Date: 24-May-2022
Date: 2022
Publication information: Cancers 2022; 14(11): 2587
Abstract: Proton therapy (PT) is a promising development in radiation oncology, with the potential to further improve outcomes for patients with squamous cell carcinoma of the head and neck (HNSCC). By utilizing the finite range of protons, healthy tissue can be spared from beam exit doses that would otherwise be irradiated with photon-based treatments. Current evidence on PT for HNSCC is limited to comparative dosimetric analyses and retrospective single-institution series. As a consequence, the recognized indications for the reimbursement of PT remain scarce in most countries. Nevertheless, approximately 100 PT centers are in operation worldwide, and initial experiences for HNSCC are being reported. This review aims to summarize the results of the early clinical experience with PT for HNSCC and the challenges that are currently faced.
DOI: 10.3390/cancers14112587
ORCID: 0000-0002-5540-4796
Journal: Cancers
PubMed URL: 35681568
PubMed URL:
ISSN: 2072-6694
Type: Journal Article
Subjects: early experience
head and neck cancer
proton therapy
Appears in Collections:Journal articles

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