Non-Invasive Serological Monitoring for Crohn's Disease Post-Operative Recurrence.

2022-06-11

Hamilton, Amy L

De Cruz, Peter P

Wright, Emily K

Dervieux, Thierry

Jain, Anjali

Kamm, Michael A

Crohn’s Disease

Disease Monitoring

Mucosal Healing

Post-Operative recurrence

Serology

Journal Article

0000-0002-1627-2057

0000-0002-3399-7236

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10.1093/ecco-jcc/jjac076

Crohn's disease recurs after intestinal resection. This study evaluated accuracy of a new blood test, the Endoscopic Healing Index (EHI), in monitoring for disease recurrence. Patients enrolled in the prospective POCER study (NCT00989560) underwent a post-operative colonoscopic assessment at 6 (2/3 of patients) and 18 months (all patients) post bowel resection using the Rutgeerts Score (recurrence ≥i2). Serum was assessed at multiple timepoints for markers of endoscopic healing using the EHI, and paired with the Rutgeerts endoscopic score as the reference standard. 131 patients provided 437 serum samples, which were paired with endoscopic assessments available in 94 patients (30 with recurrence) at 6 months and 107 patients (44 with recurrence) at 18 months. The median EHI at 6 months was significantly lower in patients in remission (Rutgeerts

link

Journal of Crohn's & Colitis 2022; 16(12)

Journal of Crohn's & Colitis